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Author Bisgaard, H.; Lerche, A.; Kristensen, J.K. url  openurl
  Title Leukotriene- and histamine-induced increases in vascular permeability and interstitial transport in the skin Type Journal Article
  Year (down) 1985 Publication The Journal of Investigative Dermatology Abbreviated Journal J Invest Dermatol  
  Volume 84 Issue 5 Pages 427-429  
  Keywords Adult; Aged; Biological Transport/drug effects; Capillary Permeability/*drug effects; Dose-Response Relationship, Drug; Extracellular Space/*drug effects; Female; Histamine/*pharmacology; Humans; Male; Middle Aged; SRS-A/*pharmacology; *Skin Window Technique  
  Abstract The aim of the present study was to investigate the edema induced by leukotriene D4 (LTD4). Edema is the gross effect of increased blood flow and capillary permeability. Our objective was to elucidate the effect of LTD4 on edema generation without the influence of the concomitantly increased blood flow induced by this potent vasodilator. A new method was outlined measuring the exudation through skin windows of a macromolecular tracer [( 131I]albumin) and a micromolecular tracer [( 99Tc]pertechnetat). Exudation of [131I]albumin is a function of enhanced vascular permeability and interstitial transport and blood flow, whereas that of [99Tc] pertechnetat is mainly a function of blood flow. Thus a ratio of the 2 exudate measurements gives a specific estimate of the changes in vascular permeability and interstitial transport. Histamine was employed to establish the method. A dose-response relation was found for histamine in the dose range of 10(-4) to 10(-7) M. The effect of 10(-5) M LTD4 on vascular permeability and interstitial transport of macromolecules was indistinguishable from that of histamine in the same concentration. This property together with their well-known vasodilatory capabilities indicate that the leukotrienes of the slow-reacting substance of anaphylaxis may play a role in the vascular changes in the allergic-inflammatory reaction.  
  Address  
  Corporate Author Thesis  
  Impact Factor 07,216 First Author Bisgaard, H. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Kristensen, J.K.  
  ISSN 0022-202X ISBN Medium  
  Area Expedition Conference  
  Notes PMID:3889168 Approved no  
  Call Number Serial 287  
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