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Author Bisgaard, H.; Kristensen, J.K. url  openurl
  Title Effects of synthetic leukotriene D-4 on the local regulation of blood flow in human subcutaneous tissue Type Journal Article
  Year (down) 1985 Publication Prostaglandins Abbreviated Journal Prostaglandins  
  Volume 29 Issue 2 Pages 155-159  
  Keywords Adult; Aged; Dinoprostone; Humans; Lidocaine/pharmacology; Middle Aged; Prostaglandins E/pharmacology; Regional Blood Flow/drug effects; SRS-A/*pharmacology; Skin/*blood supply  
  Abstract Prostaglandin E-1 and E-2 acts as vasodilators partly through inhibition of sympathetic nerves and partly through a direct action on smooth muscle. To elucidate the mechanisms of LTD-4 induced vasodilation, the vascular smooth muscle dependent auto-regulation of blood flow and the sympathetic reflex mechanism of the “vasoconstrictor reflex” was investigated in humans. Blood flow was measured in subcutaneous tissue after injection of 133-Xenon 1) alone, 2) mixed with lidocaine 20 mg/ml for sympathetic blockade, 3) mixed with PGE-2 0.1 ug/ml and 4) mixed with LTD-4 in concentrations of 5 and 20 microM. Blood flow was kept constant during elevation by 20 cm above heart level (preserved autoregulation) except after injection of PGE-2 and LTD-4 20 microM where a significant decrease was observed (defective smooth muscle function). During lowering by 45 cm, a decrease in blood flow by 50% was observed in experiment 1. This response was blocked by lidocaine and PGE-2, partially blocked by LTD-4 20 microM but unaffected by LTD 5 microM. LTD-4 affects vascular smooth muscle function but does not affect sympathetic reflexes in concentrations which does not have a direct smooth muscle action.  
  Corporate Author Thesis  
  Impact Factor 02,377 First Author Bisgaard, H. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Kristensen, J.K.  
  ISSN 0090-6980 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:3856899 Approved no  
  Call Number Serial 286  
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