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Author Bisgaard, H.; Kristensen, J.K. url  openurl
  Title Quantitation of microcirculatory blood flow changes in human cutaneous tissue induced by inflammatory mediators Type Journal Article
  Year (down) 1984 Publication The Journal of Investigative Dermatology Abbreviated Journal J Invest Dermatol  
  Volume 83 Issue 3 Pages 184-187  
  Keywords Adult; Blood Flow Velocity; Dose-Response Relationship, Drug; Erythema/*chemically induced/physiopathology; Female; Humans; Male; Microcirculation/drug effects; Middle Aged; Regional Blood Flow/drug effects; SRS-A/*pharmacology; Skin/*blood supply/drug effects; Skin Tests  
  Abstract The cutaneous microcirculation is a desirable model for pharmacologic and physiologic studies of inflammatory mediators. For exact measurements of the induced blood flow changes, two objective methods are introduced. The laser-Doppler flowmeter and the 133Xe washout technique have formerly been used for measurement of the undisturbed cutaneous blood flow. We have modified these methods to measure changes in the blood flow following intracutaneous deposition of a vasodilator, leukotriene D4. When compared with a metric estimate of the erythemal response, the two new methods were found to be more sensitive than the traditional estimate of cutaneous blood flow changes. Both methods exhibited a good sensitivity and reproducibility when applied simultaneously, although the 133Xe washout technique appeared to be able to separate interindividual differences that could not be recognized by the laser-Doppler technique. Even though the laser-Doppler technique is superior in simplicity of use, the 133Xe washout technique is recommended for exact measurements.  
  Address  
  Corporate Author Thesis  
  Impact Factor 07,216 First Author Bisgaard, H. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Kristensen, J.K.  
  ISSN 0022-202X ISBN Medium  
  Area Expedition Conference  
  Notes PMID:6470522 Approved no  
  Call Number Serial 285  
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