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Author Svenson, M.; Bisgaard, H.; Bendtzen, K. url  openurl
  Title Effects of leukotrienes on neutrophil migration, and on production and action of lymphokines Type Journal Article
  Year (down) 1984 Publication Allergy Abbreviated Journal Allergy  
  Volume 39 Issue 6 Pages 481-484  
  Keywords Antibody Formation; Blood Cells/metabolism; Cyclic AMP/biosynthesis; Cyclic GMP/biosynthesis; Granulocytes/metabolism; Humans; Leukocyte Migration-Inhibitory Factors/*physiology; Leukotriene B4/*pharmacology; Lymphokines/*physiology  
  Abstract The effect of the leukotrienes LTB4, LTC4 and LTD4 on the production of the lymphokine leukocyte migration inhibitory factor (LIF) from human peripheral blood mononuclear cells was tested. LTC4 and LTD4 failed to influence LIF production by cells stimulated by antigen or the polyclonal T cell activator, phytohemagglutinin (PHA). LTB4, at concentrations 10(-7) to 10(-6) M, showed significant inhibition of antigen-induced LIF production but was without effect when cells were stimulated by PHA. The cell levels of cyclic adenosine monophosphate (cAMP) were unaffected by 2.5 X 10(-7) M LTB4 in the absence or presence of theophylline. These results indicate that LTB4 acts on the early effector stage of the immune response without affecting the cellular cAMP content.  
  Corporate Author Thesis  
  Impact Factor 06,028 First Author Svenson, M. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Bendtzen, K.  
  ISSN 0105-4538 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:6093614 Approved no  
  Call Number Serial 284  
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