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Author Bisgaard, H. url  openurl
  Title Leukotrienes and prostaglandins in asthma Type Journal Article
  Year (down) 1984 Publication Allergy Abbreviated Journal Allergy  
  Volume 39 Issue 6 Pages 413-420  
  Keywords Anti-Inflammatory Agents/pharmacology; Arachidonic Acid; Arachidonic Acids/biosynthesis/metabolism; Asthma/complications/*physiopathology; Autacoids/metabolism; Bronchial Spasm/chemically induced; Ciliary Motility Disorders/etiology; Cyclooxygenase Inhibitors; Edema/chemically induced; Enzyme Inhibitors; Histamine Release; Humans; Leukotriene B4/*physiology; *Leukotrienes; Mast Cells/metabolism; Prostaglandins/*physiology  
  Abstract Leukotrienes and prostaglandins possess properties which are central in the asthmatic reaction. They are bronchoconstrictors, they inhibit the mucociliary clearance, increase blood flow and permeability and thereby induce edema formation, and they attract and activate leukocytes. They are formed partly by allergic reactions and partly by a large number of other more non-specific reactions. Finally, the concentration of prostanoids has been found increased in the asthmatic reaction in vivo. The leukotrienes have not been traced in vivo in asthmatic attacks so far, but have been found in vivo in man in a specific type I allergic conjunctival reaction. Much evidence suggests that these mediators are relevant in asthmatic diseases, even though prostaglandin inhibitors have no effect in asthma. There still remains the need to investigate the influence on asthmatic diseases by as yet unavailable leukotriene blocking agents. Even though leukotrienes are judged today to be important mediators in asthma, it does not seem reasonable to expect that a single mediator is responsible for asthmatic diseases. Rather, it seems quite likely that asthma is caused by a complex interplay of a large number of mediators, circulating hormones, nervous mechanisms, receptor abnormalities, intracellular metabolic defects, etc. Despite this complexity, investigations in recent years have increased the knowledge of the biochemistry and human physiological effects of leukotrienes and prostaglandins which has created an improved understanding of the asthmatic reaction's pathophysiology, contributed a pharmacological rationale for previously used therapy, and stimulated new perspectives for specific pharmacological research.  
  Corporate Author Thesis  
  Impact Factor 06,028 First Author Bisgaard, H. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Bisgaard, H.  
  ISSN 0105-4538 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:6208802 Approved no  
  Call Number Serial 283  
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