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Author Lerche, A.; Bisgaard, H.; Christensen, J.D.; Sondergaard, J. url  openurl
  Title Human leukocyte cyclic AMP and cyclic GMP levels during chemotaxis in delayed type hypersensitivity Type Journal Article
  Year (down) 1984 Publication Allergy Abbreviated Journal Allergy  
  Volume 39 Issue 3 Pages 195-201  
  Keywords Adult; Aged; Cell Movement; Chemotaxis, Leukocyte; Cyclic AMP/*blood; Cyclic GMP/*blood; Dermatitis, Contact/etiology; Female; Humans; Hypersensitivity, Delayed/*blood/immunology; Leukocytes/*analysis/cytology; Male; Middle Aged; Nickel/adverse effects; Skin Tests  
  Abstract Ten nickel-allergic patients and six healthy control subjects participated in a study of the morphology, kinetics and evolution of the cAMP and cGMP concentrations of migrated leukocytes, using an improved skin chamber technique. Also studied was the effect of nickel exposure in the chamber medium during development of an eczematous reaction in the nickel-allergic patients. Nickel exposure had a specific effect on the morphology, from the 24th hour to the end of the 48 h observation period, with a significant increase in the percentages of basophils, eosinophils and lymphocytes and a decrease of neutrophils. A significantly increased leukocyte migration rate (LMR) was observed from the 27th to 39th hour in six of the allergic patients exposed to nickel. There were no specific permanent changes in cAMP and cGMP concentrations during nickel exposure. The control chambers of the allergic patients and healthy controls had identical leukocyte morphology, LMR and leukocyte concentrations of cAMP and cGMP. However, no correlations were found between LMR, cAMP and cGMP in the eczema patients throughout the observation period.  
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  Corporate Author Thesis  
  Impact Factor 06,028 First Author Lerche, A. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Sondergaard, J.  
  ISSN 0105-4538 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:6324609 Approved no  
  Call Number Serial 281  
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