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Author Lerche, A.; Bisgaard, H.; Christensen, J.D.; Sondergaard, J. url  openurl
  Title Human leukocyte mobilization and morphology in nickel contact allergy using a skin chamber technique Type Journal Article
  Year (down) 1981 Publication Acta Dermato-Venereologica Abbreviated Journal Acta Derm Venereol  
  Volume 61 Issue 6 Pages 517-523  
  Keywords Adult; Aged; *Cell Migration Inhibition; Dermatitis, Contact/*diagnosis/etiology/immunology; Female; Humans; Leukocyte Count; Leukocytes/*immunology; Male; Middle Aged; Nickel/*adverse effects; Skin Tests/*methods  
  Abstract An improved skin chamber technique has been devised and used for quantitative evaluation of the leukocyte mobilization rate (LMR). The method was applied in 10 nickel-hypersensitive patients exposed to nickel sulphate. Each patient served as his own control and for additional control purpose, 5 healthy individuals without nickel hypersensitivity were studied. The kinetics of the mobilized leukocytes were followed over a 48-hour period. After an initial lag phase of 2-4 hours, maximum migration was observed from the 24th to the 48th hour, with a wide interindividual variability in the number of mobilized cells at the time of maximum LMR response. The median cumulative leukocyte count was 1.412 x 10(6) leukocytes/cm2/48 h. In the same period a statistically significant increase in the basophils for all the nickel allergic patients was observed. In 8 out of 10 patients a statistically significant effect upon the lymphocytes could be demonstrated. Six of these 8 patients had an increased lymphocyte mobilization. Throughout the period the neutrophil granulocytes were the dominant cell type, although the number decreased as the number of basophils and lymphocytes increased. The chamber technique is a valuable means for quantitative evaluation of leukocyte mobilization and morphology in skin exudates during exposure to an allergen in delayed hypersensitivity reactions.  
  Corporate Author Thesis  
  Impact Factor 03,025 First Author Lerche, A. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Sondergaard, J.  
  ISSN 0001-5555 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:6177163 Approved no  
  Call Number Serial 274  
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