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Author Chawes, B.L.K.; Stokholm, J.; Bonnelykke, K.; Brix, S.; Bisgaard, H. url  doi
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  Title Neonates with reduced neonatal lung function have systemic low-grade inflammation Type Journal Article
  Year (down) 2015 Publication The Journal of Allergy and Clinical Immunology Abbreviated Journal J Allergy Clin Immunol  
  Volume 135 Issue 6 Pages 1450-6.e1  
  Keywords Adult; Asthma/*blood/complications/diagnosis/physiopathology; Biomarkers/blood; Birth Weight; Body Mass Index; C-Reactive Protein/*metabolism; Denmark; Female; Forced Expiratory Volume; Humans; Infant; Infant, Newborn; Inflammation/blood/complications/diagnosis/physiopathology; Interleukin-1beta/blood; Interleukin-6/blood; Interleukin-8/blood; Male; Maternal Exposure; Multivariate Analysis; Principal Component Analysis; Prospective Studies; Smoking/physiopathology; Tumor Necrosis Factor-alpha/blood; Asthma; children; high-sensitivity C-reactive protein; proinflammatory cytokines; spirometry  
  Abstract BACKGROUND: Children and adults with asthma and impaired lung function have been reported to have low-grade systemic inflammation, but it is unknown whether this inflammation starts before symptoms and in particular whether low-grade inflammation is present in asymptomatic neonates with reduced lung function. OBJECTIVE: We sought to investigate the possible association between neonatal lung function and biomarkers of systemic inflammation. METHODS: Plasma levels of high-sensitivity C-reactive protein (hs-CRP), IL-1beta, IL-6, TNF-alpha, and CXCL8 (IL-8) were measured at age 6 months in 300 children of the Copenhagen Prospective Study on Asthma in Childhood2000 birth cohort who had completed neonatal lung function testing at age 4 weeks. Associations between neonatal lung function indices and inflammatory biomarkers were investigated by conventional statistics and unsupervised principal component analysis. RESULTS: The neonatal forced expiratory volume at 0.5 seconds was inversely associated with hs-CRP (beta-coefficient, -0.12; 95% CI, -0.21 to -0.04; P < .01) and IL-6 (beta-coefficient, -0.10; 95% CI, -0.18 to -0.01; P = .03) levels. The multivariate principal component analysis approach, including hs-CRP, IL-6, TNF-alpha, and CXCL8, confirmed a uniform upregulated inflammatory profile in children with reduced forced expiratory volume at 0.5 seconds (P = .02). Adjusting for body mass index at birth, maternal smoking, older children in the home, neonatal bacterial airway colonization, infections 14 days before, and asthmatic symptoms, as well as virus-induced wheezing, at any time before biomarker assessment at age 6 months did not affect the associations. CONCLUSION: Diminished neonatal lung function is associated with upregulated systemic inflammatory markers, such as hs-CRP.  
  Address Copenhagen Prospective Studies on Asthma in Childhood, Health and Medical Sciences, University of Copenhagen & Danish Pediatric Asthma Center, Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark. Electronic address: bisgaard@copsac.com  
  Corporate Author Thesis  
  Impact Factor 11,476 First Author Chawes, B.L.K. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Bisgaard, H.  
  ISSN 0091-6749 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:25579483 Approved no  
  Call Number Serial 27  
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