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Author Nielsen, K.G.; Skov, M.; Klug, B.; Ifversen, M.; Bisgaard, H. url  openurl
  Title Flow-dependent effect of formoterol dry-powder inhaled from the Aerolizer Type
  Year (down) 1997 Publication The European Respiratory Journal Abbreviated Journal Eur Respir J  
  Volume 10 Issue 9 Pages 2105-2109  
  Keywords Administration, Inhalation; Adolescent; Asthma, Exercise-Induced/*drug therapy/physiopathology; Bronchodilator Agents/*administration & dosage; Child; Child, Preschool; Cross-Over Studies; Double-Blind Method; Ethanolamines/*administration & dosage; Female; Forced Expiratory Volume/drug effects; Formoterol Fumarate; Humans; Male; *Nebulizers and Vaporizers; Powders; Pulmonary Ventilation/drug effects  
  Abstract The output and size distribution of aerosols from dry powder inhalers are dependent on the flow rate through the device. Therefore, in an in vivo study, we examined the flow-dependency of the effect of formoterol when delivered from a dry powder inhaler, the Aerolizer, in a flow range relevant to schoolchildren. In a preliminary study comprising 126 asthmatic children aged 3-10 yrs, the relationship between age and peak inspiratory flow (PIF) rate through the Aerolizer was determined. Mean PIF was 104 L.min-1 and all children aged > 5 yrs performed a PIF > 60 L.min-1. Sixteen children aged 8-15 yrs with exercise-induced asthma (EIA) took part in the main trial comparing the protective effect of 12 micrograms formoterol inhaled at 60 and 120 L.min-1. The effect from high and low inspiratory flow was judged from the protective effect against EIA 12 h after drug administration. The decrease in forced expiratory volume in one second (FEV1) after exercise was 34% on the placebo day, but only 15% when formoterol was inhaled at the high flow rate. This difference was statistically significant. The decrease in FEV1 was 23% after treatment with formoterol inhaled at the low flow rate, that was not significantly different from placebo or from high-flow formoterol treatment. These clinical findings correspond with the in vitro findings of flow-dependent fine particle mass from the Aerolizer, and corroborate the relationship between fine particle mass of aerosol and clinical effect. The results indicate a flow-dependent effect of formoterol dry powder inhaled from the Aerolizer, within the range of inspiratory flow rate obtainable by school-children. This questions its applicability in children with asthma.  
  Address Dept of Paediatrics, National University Hospital, Copenhagen, Denmark  
  Corporate Author Thesis  
  Impact Factor 07,636 First Author Nielsen, K.G. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Bisgaard, H.  
  ISSN 0903-1936 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:9311511 Approved no  
  Call Number Serial 269  
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