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Author Klug, B.; Bisgaard, H. url  openurl
  Title Measurement of the specific airway resistance by plethysmography in young children accompanied by an adult Type Journal Article
  Year (down) 1997 Publication The European Respiratory Journal Abbreviated Journal Eur Respir J  
  Volume 10 Issue 7 Pages 1599-1605  
  Keywords Adult; *Airway Resistance; Asthma/*diagnosis; Child; Child, Preschool; Female; Humans; Male; *Patient Compliance; Plethysmography, Whole Body/*methods/statistics & numerical data; Reproducibility of Results  
  Abstract The purpose of this study was to evaluate a procedure for measurement of specific airway resistance (sRaw) by whole body plethysmography in young awake children accompanied by an adult. sRaw was measured by a single-step procedure, omitting the measurement of the thoracic gas volume. The frequency dependency of sRaw was investigated and the accuracy of simulating body temperature, atmospheric pressure and saturation with water vapour (BTPS) conditions by electronic compensation was assessed. One hundred and thirty one children with asthma were studied. In 57 children (mean (SD) age 5.6 (1.8) yrs) who performed measurements with and without an accompanying adult, the mean value of sRaw was 1.45 (0.36) and 1.44 (0.38) kPa x s, respectively, with a mean difference of 0.008 (0.152) kPa x s, and mean within-subject coefficients of variations (CV) of 8% and 10%, respectively. In 52 children (mean age 3.3 (0.8) yrs), for whom measurements made only in the presence of an accompanying adult, the CV was 8.5%. No measurements could be obtained in 22 children (17%) (mean age 2.8 (0.5) yrs). Measurements exhibited a significant frequency dependency, and electronic BTPS compensation substantially overestimated SRaw. In conclusion, the use of electronic compensation for simulating body temperature, atmospheric pressure and saturation with water vapour introduces a bias that affects the accuracy of the estimate of specific airway resistance. Nevertheless, plethysmographic measurements with and without an accompanying adult yielded comparable and equally repeatable estimates of specific airway resistance. The single-step plethysmographic procedure with an accompanying adult is a clinically useful method for evaluating airway function in children too young to perform plethysmographic measurements alone.  
  Address National University Hospital, Rigshospitalet, Copenhagen, Denmark  
  Corporate Author Thesis  
  Impact Factor 07,636 First Author Klug, B. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Bisgaard, H.  
  ISSN 0903-1936 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:9230254 Approved no  
  Call Number Serial 268  
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