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Author Klug, B.; Bisgaard, H. url  openurl
  Title Repeatability of methacholine challenges in 2- to 4-year-old children with asthma, using a new technique for quantitative delivery of aerosol Type Journal Article
  Year (down) 1997 Publication Pediatric Pulmonology Abbreviated Journal Pediatr Pulmonol  
  Volume 23 Issue 4 Pages 278-286  
  Keywords Aerosols; Asthma/*diagnosis; Bronchial Provocation Tests/*methods; *Bronchoconstrictor Agents/administration & dosage; Child, Preschool; Female; Humans; Male; *Methacholine Chloride/administration & dosage; Reproducibility of Results; Terbutaline/administration & dosage  
  Abstract To determine the repeatability of bronchial responsiveness in awake young children, two methacholine challenge tests were performed on separate days in 16 children with stable asthma (mean age, 3 3/4 years). Methacholine was administered using a new method for quantitative delivery of aerosol that eliminates the effect of dilution of the aerosol by entrainment of air and enables quantitative delivery of aerosol according to body weight. Respiratory function was monitored by measurement of respiratory resistance by the interrupter technique (Rint), respiratory resistance and reactance at 5 Hz (Rrs5, Xrs5) by the impulse oscillation technique, transcutaneous measurements of oxygen (PtcO2), and specific airway resistance (sRaw). Repeatability was evaluated by determining the provocative dose that caused a defined percentage of change relative to baseline (PD%: Rint PD30, Rrs5 PD30, Xrs5 PD80, PtcO2 PD10, and sRaw PD80. Repeatability was estimated from the difference between the PD% obtained at the time of the two tests. Using the numeric value of these differences, the repeatability of Xrs5 PD60, PtcO2 PD10, and sRaw PD50 was [mean (SD)]: [0.8 (0.5)] [0.5 (0.4)] and [0.7 (0.6)] doubling doses, respectively. Rint PD30 and Rrs5 PD30 proved to be less reproducible: [1.2 (1)] and [1.6 (0.9)] doubling doses, respectively. The new method of aerosol delivery offers a means of standardizing the bronchoconstrictor stimulus, and the results show that estimates of bronchial responsiveness in young children can be obtained reproducibly within one doubling dose of methacholine.  
  Address Department of Pediatrics, National University, Copenhagen, Denmark  
  Corporate Author Thesis  
  Impact Factor 02,704 First Author Klug, B. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Bisgaard, H.  
  ISSN 1099-0496 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:9141113 Approved no  
  Call Number Serial 267  
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