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Author Daugbjerg, P.; Nielsen, K.G.; Skov, M.; Bisgaard, H. url  openurl
  Title Duration of action of formoterol and salbutamol dry-powder inhalation in prevention of exercise-induced asthma in children Type
  Year (down) 1996 Publication Acta Paediatrica Abbreviated Journal Acta Paediatr  
  Volume 85 Issue 6 Pages 684-687  
  Keywords Administration, Inhalation; Adolescent; Albuterol/*therapeutic use; Asthma, Exercise-Induced/*prevention & control; Bronchodilator Agents/*therapeutic use; Child; Cross-Over Studies; Double-Blind Method; Ethanolamines/*therapeutic use; Exercise Test; Female; Forced Expiratory Volume/drug effects; Formoterol Fumarate; Humans; Male; Nebulizers and Vaporizers; Powders; Time Factors  
  Abstract The aim of this study was to evaluate the effect and tolerability of formoterol 12 micrograms on exercise-induced asthma in children for 12 h as compared to the effect of salbutamol 400 micrograms and placebo. The drugs were inhaled as dry powder from a flow-dependent metered-dose inhaler (DP-MDI). Sixteen asthmatic children took part in a double-blind placebo-controlled within-patient single-centre trial. On each study day the patients were given one of the drugs or placebo in random order, and standardized exercise tests were performed after 3 and 12 h. At a pretrial test the children had demonstrated a median maximum percentage fall of 38% (range 22-79%) in forced expiratory volume in 1 s after exercise challenge. Formoterol showed a median percentage protection of 77% and 70% at 3 and 12 h postexercise, respectively, as compared to 46% and 13% with salbutamol. No side-effects were observed. Formoterol 12 micrograms administered as dry powder offers significantly better protection against exercise-induced asthma after 3 and 12 h as compared to salbutamol 400 micrograms and placebo.  
  Address Department of Paediatrics, National University Hospital, Rigshospitalet, Copenhagen, Denmark  
  Corporate Author Thesis  
  Impact Factor 01,674 First Author Daugbjerg, P. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Bisgaard, H.  
  ISSN 0803-5253 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:8816204 Approved no  
  Call Number Serial 261  
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