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Author Nysom, K.; Holm, K.; Hesse, B.; Ulrik, C.S.; Jacobsen, N.; Bisgaard, H.; Hertz, H. url  openurl
  Title Lung function after allogeneic bone marrow transplantation for leukaemia or lymphoma Type Journal Article
  Year (down) 1996 Publication Archives of Disease in Childhood Abbreviated Journal Arch Dis Child  
  Volume 74 Issue 5 Pages 432-436  
  Keywords Adolescent; Bone Marrow Transplantation/*adverse effects/physiology; Child; Child, Preschool; Cohort Studies; Female; Follow-Up Studies; Humans; Leukemia/*therapy; Lung/*physiopathology; Lung Diseases/*etiology; Lymphoma, T-Cell/*therapy; Male; Radiation Injuries/etiology; Survivors; Whole-Body Irradiation/adverse effects  
  Abstract Longitudinal data were analysed on the lung function of 25 of 29 survivors of childhood leukaemia or lymphoma, who had been conditioned with cyclophosphamide and total body irradiation before allogeneic bone marrow transplantation, to test whether children are particularly vulnerable to pulmonary damage after transplantation. None developed chronic graft-versus-host disease. Transfer factor and lung volumes were reduced immediately after bone marrow transplantation, but increased during the following years. However, at the last follow up, 4-13 years (median 8) after transplantation, patients had significantly reduced transfer factor, total lung capacity, and forced vital capacity (-1.0, -1.2, and -0.8 SD score, respectively), and increased ratio of forced expiratory volume in one second to forced vital capacity (+0.9 SD score). None of the patients had pulmonary symptoms, and changes were unrelated to their age at bone marrow transplantation. In conclusion, patients had subclinical restrictive pulmonary disease at a median of eight years after total body irradiation and allogeneic bone marrow transplantation.  
  Address National University Hospital Rigshospitalet, Copenhagen, Denmark  
  Corporate Author Thesis  
  Impact Factor 02,899 First Author Nysom, K. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Hertz, H.  
  ISSN 0003-9888 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:8669960; PMCID:PMC1511542 Approved no  
  Call Number Serial 260  
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