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Author Klug, B.; Bisgaard, H. url  doi
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  Title Measurement of lung function in awake 2-4-year-old asthmatic children during methacholine challenge and acute asthma: a comparison of the impulse oscillation technique, the interrupter technique, and transcutaneous measurement of oxygen versus whole-body plethysmography Type Journal Article
  Year (down) 1996 Publication Pediatric Pulmonology Abbreviated Journal Pediatr Pulmonol  
  Volume 21 Issue 5 Pages 290-300  
  Keywords Acute Disease; Airway Resistance/drug effects/physiology; Asthma/diagnosis/drug therapy/*physiopathology; Blood Gas Monitoring, Transcutaneous; *Bronchial Provocation Tests; Bronchodilator Agents/therapeutic use; Child, Preschool; Dose-Response Relationship, Drug; Humans; *Methacholine Chloride; Oscillometry; Plethysmography, Whole Body; *Respiratory Function Tests; Terbutaline/therapeutic use  
  Abstract This study evaluated three techniques for testing of lung function in young awake children. We compared measurements by the forced or impulse oscillation technique (IOS), the interrupter technique (IT), and transcutaneous measurements of oxygen (tcPo2) with concomitant measurements of specific airway resistance (sRaw) during methacholine challenge in 20 stable asthmatic children, 2-4 years old. Measurements were performed with all techniques after each dose of methacholine and after inhalation of a bronchodilator. Measurements were carried out during tidal breathing using a face-mask with a built-in mouthpiece. The ranking of sensitivity was as follows: sRaw > IOS, respiratory reactance at 5 Hz (Xrs5) > tcPo2 > interrupter resistance (Rint) > IOS, respiratory resistance at 5 Hz (Rrs5). The sensitivity of sRaw and Xrs5 was not significantly different, but both were significantly more sensitive than Rint and Rrs5; the sensitivity of tcPo2, Rint, and Rrs5 was not significantly different. Measurements in eight of the subjects performed during an episode of acute asthma yielded comparable results in regard to the sensitivity of the techniques. Measurements improved significantly after bronchodilator administration; however, the response to bronchodilator tended to be less during acute asthma and was best demonstrated by a deterioration of tcPo2. All the evaluated techniques reliably reflect short-term changes in respiratory function and can provide clinically useful estimates of airway function. The techniques are non-invasive, are not dependent on the active co-operation or sedation of the subjects, and therefore are well suited for routine use in young children.  
  Address Department of Pediatrics, National University Hospital, Copenhagen, Denmark  
  Corporate Author Thesis  
  Impact Factor 02,704 First Author Klug, B. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Bisgaard, H.  
  ISSN 1099-0496 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:8726154 Approved no  
  Call Number Serial 259  
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