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Author Bisgaard, H.; Anhoj, J.; Klug, B.; Berg, E. url  openurl
  Title A non-electrostatic spacer for aerosol delivery Type
  Year (down) 1995 Publication Archives of Disease in Childhood Abbreviated Journal Arch Dis Child  
  Volume 73 Issue 3 Pages 226-230  
  Keywords Aerosols/*administration & dosage; Asthma/drug therapy; Bronchodilator Agents/administration & dosage; Budesonide; Child; Child, Preschool; Female; Humans; Infant; Male; *Nebulizers and Vaporizers; Pregnenediones/administration & dosage  
  Abstract A pear shaped non-electrostatic spacer, composed of steel with a volume of 250 ml and equipped with a facemask containing integrated inlet and outlet valves for inspiration and expiration, was compared with three plastic spacers. The plastic spacers were primed with repeated puffs from a budesonide pressurised metered dose inhaler (p-MDI) to minimise the electrostatic charge on the plastic. The procedure prolonged the half life (t1/2) of the aerosol in the Nebuhaler from nine to 32 seconds. A normal cleaning procedure reduced the aerosol t1/2 back to baseline. The t1/2 of the aerosol in the metal spacer was 27 seconds and independent of the use of p-MDI. In vitro the maximum dose of budesonide from a p-MDI, expressed as a percentage of the nominal dose, was 56% from the non-electrostatic spacer, 61% from the Nebuhaler, 45% from the Babyhaler, and 30% from the AeroChamber. In 124 children, age 6 months to 6 years, suspected to have asthma the non-electrostatic spacer delivered a mean total dose of budesonide aerosol of 39% of the nominal dose, which was significantly higher than the Babyhaler (28%), the Nebuhaler (21%), and the AeroChamber (19%). These differences were most pronounced in children younger than 4 years. The improved dose delivery from the small volume non-electrostatic spacer is probably related to the non-electrostatic spacer material and the valves which assured unidirectional airflow from the spacer without adding any dead space in the inspiratory channel. The non-electro-static spacer should improve the cost effectiveness of aerosol treatment and, as the counteracting effects of proming and recharging of the plastic from cleaning are avoided, should deliver a more reliable dose.  
  Address Department of Paediatrics, National University Hospital, Copenhagen, Denmark  
  Corporate Author Thesis  
  Impact Factor 02,899 First Author Bisgaard, H. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Berg, E.  
  ISSN 0003-9888 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:7492160; PMCID:PMC1511307 Approved no  
  Call Number Serial 255  
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