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Author Bisgaard, H. url  openurl
  Title A metal aerosol holding chamber devised for young children with asthma Type Journal Article
  Year (down) 1995 Publication The European Respiratory Journal Abbreviated Journal Eur Respir J  
  Volume 8 Issue 5 Pages 856-860  
  Keywords Administration, Inhalation; Aerosols; Asthma/*drug therapy; Bronchodilator Agents/*administration & dosage/therapeutic use; Budesonide; Child; Child, Preschool; Cross-Over Studies; Equipment Design; Female; Humans; Infant; Male; *Nebulizers and Vaporizers; Pregnenediones/*administration & dosage/therapeutic use; Single-Blind Method; *Steel  
  Abstract The low tidal volume and flow in preschool children may reduce the efficiency of aerosol delivery from a pressurized metered-dose inhaler (pMDI) through a traditional holding chamber. A prototype small-volume steel holding chamber with two one-way valves was devised to prolong aerosol availability in the chamber and to ensure unidirectional airflow. Dead space between the valves was minimized to less than 2 ml. The dose-delivery and rate of passive disappearance of a budesonide pMDI aerosol were compared between this prototype and the large-volume, single-valved plastic Nebuhaler, in 164 asthmatic children less than 8 yrs of age. In vitro, the half life of aerosol disappearance in the steel prototype and the plastic Nebuhaler was > 30 s and 9 s, respectively. In vivo, the prototype delivered an age-independent mean dose of 38% of the nominal dose, and the Nebuhaler delivered an age-dependent mean dose, ranging from 42% of the nominal dose in children > or = 4 yrs to 19% of the nominal dose in infants. We conclude that the use of plastic for holding chambers may influence dose-delivery, and single-valve control may cause age-dependent dose-delivery. Reproducible age-independent drug-delivery may be achieved by pMDI aerosol inhaled through a small-volume metal holding chamber with separate inlet and outlet valves and minimized dead space. This holding chamber would improve the possibilities of aerosol therapy for young children.  
  Address Dept of Paediatrics, National University Hospital, Copenhagen, Denmark  
  Corporate Author Thesis  
  Impact Factor 07,636 First Author Bisgaard, H. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Bisgaard, H.  
  ISSN 0903-1936 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:7656962 Approved no  
  Call Number Serial 254  
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