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Author Bisgaard, H.; Pedersen, S.; Nikander, K. url  openurl
  Title Use of budesonide Turbuhaler in young children suspected of asthma Type Journal Article
  Year (down) 1994 Publication The European Respiratory Journal Abbreviated Journal Eur Respir J  
  Volume 7 Issue 4 Pages 740-742  
  Keywords Asthma/*drug therapy; Bronchodilator Agents/*administration & dosage; Budesonide; Child; Child, Preschool; Humans; Infant; Nebulizers and Vaporizers; Powders; Pregnenediones/*administration & dosage  
  Abstract The question addressed in this study was the ability of young children to use a dry-powder inhaler, Turbuhaler. One hundred and sixty five children suspected of asthma, equally distributed in one year age-groups from 6 months to 8 yrs, inhaled from a Pulmicort Turbuhaler, 200 micrograms budesonide-dose-1, through a filter. The amount of drug trapped by the filter was used as a measure of drug released to the patient. None of the children had prior experience in the use of a Turbuhaler, but they were instructed carefully, together with their parents, in the clinic. The median dose released revealed an age-dependent increase, with a considerable scatter. Accordingly, the dose delivered could not be predicted in these young children. The limitation to effective use in young children appeared to be lack of sufficient co-operation, rather than physical limitations, as even some very young children appeared to obtain a sufficient activation of the device. It is likely that repeated training at home may improve these findings. In conclusion, our results indicate that dry-powder inhalers are not reliable in all circumstances for treatment of young children, and that careful and repeated tuition is required if such devices are to be used.  
  Address Dept of Paediatrics, State University Hospital, Copenhagen, Denmark  
  Corporate Author Thesis  
  Impact Factor 07,636 First Author Bisgaard, H. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Nikander, K.  
  ISSN 0903-1936 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:8005258 Approved no  
  Call Number Serial 253  
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