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Author Bisgaard, H. url  openurl
  Title Systemic activity of inhaled topical steroid in toddlers studied by knemometry Type
  Year (down) 1993 Publication Acta Paediatrica Abbreviated Journal Acta Paediatr  
  Volume 82 Issue 12 Pages 1066-1071  
  Keywords Administration, Inhalation; Administration, Topical; Anthropometry/instrumentation/*methods; Anti-Inflammatory Agents/administration & dosage/*adverse effects; Budesonide; Child, Preschool; Depression, Chemical; Dose-Response Relationship, Drug; Double-Blind Method; Glucocorticoids; Humans; Infant; Leg/*growth & development; Pregnenediones/administration & dosage/*adverse effects; Recurrence; Respiratory Sounds  
  Abstract The short-term linear growth rate of the lower leg in toddlers was measured and evaluated in order to study the possible effect of inhaled budesonide on this factor in toddlers with mild recurrent wheezing. The short-term linear growth rate of the lower leg was measured weekly using a hand-held knemometer. Eighteen toddlers aged 13-36 months (mean 27 months) with a history of recurrent wheezing requiring inhaled topical steroids, but without need of regular medication during the months prior to the study, were studied. The children were randomized blindly through three consecutive treatment periods of four weeks with placebo or budesonide in daily doses of 200 micrograms and 800 micrograms administered as a pressurized aerosol inhaled via a spacer with a face mask. Twenty-nine percent (median) of the nominal dose was delivered at the mouth of the children. Three children were withdrawn because of exacerbations and one because of non-compliance. The precision of the measurement procedure was 51 microns/day. The mean growth rate during placebo, low-dose and high-dose steroid treatment was 92 microns/day, 114 microns/day and 46 microns/day respectively. The growth rate during the high-dose treatment was suppressed significantly compared to placebo treatment (95% CI -76 microns/day to -17 microns/day), whereas the growth rate during low-dose steroid treatment was indistinguishable from placebo treatment (95% CI -7 to +52 microns/day). In conclusion, measurement of short-term linear growth rate by knemometry in toddlers is a fast and gentle method with a high level of precision.(ABSTRACT TRUNCATED AT 250 WORDS)  
  Address Department of Paediatrics, Rigshospitalet, State University Hospital of Copenhagen, Denmark  
  Corporate Author Thesis  
  Impact Factor 01,674 First Author Bisgaard, H. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Bisgaard, H.  
  ISSN 0803-5253 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:8155929 Approved no  
  Call Number Serial 251  
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