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Author Gronborg, H.; Bisgaard, H.; Romeling, F.; Mygind, N. url  openurl
  Title Early and late nasal symptom response to allergen challenge. The effect of pretreatment with a glucocorticosteroid spray Type
  Year (down) 1993 Publication Allergy Abbreviated Journal Allergy  
  Volume 48 Issue 2 Pages 87-93  
  Keywords Administration, Topical; Adolescent; Adult; Airway Resistance; Allergens/immunology; Anti-Inflammatory Agents/*therapeutic use; Budesonide; Double-Blind Method; Female; Glucocorticoids; Humans; Hypersensitivity/*drug therapy; Male; Nasal Provocation Tests; Nose/drug effects/*immunology; Pregnenediones/*therapeutic use  
  Abstract We challenged 30 pollen-sensitive volunteers with allergen, recorded symptoms and signs over a 10-h period, and rechallenged them after 24 h, in order to characterize the early and late allergic symptom response in the nose. The challenge was performed after topical pretreatment with the glucocorticosteroid budesonide (200 micrograms twice daily) for 14 d and with placebo in a double-blind, cross-over trial. The early response, consisting of sneezing, discharge, and blockage, was followed by a weak late response, consisting of a few sneezes and nose-blowings, and of a sustained nasal blockage. These symptoms did not have a well-defined peak in time, and a biphasic symptom curve could not be identified. The rechallenge response showed increased nasal responsiveness. The degree of budesonide effect on the early response varied, depending on the symptom; there was a marked effect on sneezing (72% reduction; P < 0.01), a moderate effect on discharge (37% reduction; P < 0.01), and a slight effect on blockage (17% reduction of nasal inspiratory peak flow rate; P < 0.02). The degree of inhibition of the rechallenge response was similar to the effect on the initial early response. The effect on the late response was very pronounced for all symptoms and signs (97% reduction of sneezes, 76% reduction of nose-blowings, 96% reduction of blockage; P < 0.01). In conclusion, we found it difficult in the individual subject to identify a well-defined late symptom response by criteria similar to those employed to characterize the late response in the bronchi. The effect of budesonide was more marked on sneezing than on blockage, and the drug was considerably more effective on the late response than on the early response.  
  Address Department of Otorhinolaryngology, Rigshospitalet, Copenhagen, Denmark  
  Corporate Author Thesis  
  Impact Factor 06,028 First Author Gronborg, H. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Mygind, N.  
  ISSN 0105-4538 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:8457038 Approved no  
  Call Number Serial 249  
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