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Author Bisgaard, H.; Pedersen, S.; Damkjaer Nielsen, M.; Osterballe, O. url  openurl
  Title Adrenal function in asthmatic children treated with inhaled budesonide Type
  Year (down) 1991 Publication Acta Paediatrica Scandinavia Abbreviated Journal Acta Paediatr Scand  
  Volume 80 Issue 2 Pages 213-217  
  Keywords Administration, Inhalation; Adolescent; Adrenal Glands/*drug effects; Analysis of Variance; Asthma/*drug therapy; Bronchodilator Agents/administration & dosage/*pharmacology; Budesonide; Child; Circadian Rhythm; Creatinine/urine; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume/drug effects; Humans; Hydrocortisone/urine; Male; Pregnenediones/administration & dosage/*pharmacology; Prospective Studies; Single-Blind Method  
  Abstract The effect of the inhaled topical steroid budesonide on adrenal function was evaluated in 33 children (aged 7-15 years) with moderate bronchial asthma. The trial was designed as a prospective single-blind study of the effect of budesonide in daily doses of 200 microgram through 400 microgram to 800 micrograms in three randomized consecutive periods of 8 weeks. The unstimulated diurnal production of cortisol was assessed by measurement of free cortisol in 24-hour urine samples at the end of each period. No significant dose-related suppression was found. The cortisol production did not differ significantly during treatment with 800 microgram budesonide as compared to treatment with 200 microgram budesonide (95% confidence interval: 74%-112%). It is concluded, that budesonide is a topical steroid with a favourable ratio between topical and systemic effects in asthmatic children.  
  Address Department of Paediatrics, University Hospital of Copenhagen, Denmark  
  Corporate Author Thesis  
  Impact Factor 01,770 First Author Bisgaard, H. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Osterballe, O.  
  ISSN 0001-656X ISBN Medium  
  Area Expedition Conference  
  Notes PMID:2035313 Approved no  
  Call Number Serial 245  
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