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Author Clementsen, P.; Milman, N.; Struve-Christensen, E.; Petersen, B.N.; Pedersen, M.; Bisgaard, H.; Permin, H.; Norn, S. url  openurl
  Title Bacteria-induced histamine release from human bronchoalveolar cells and blood leukocytes Type Journal Article
  Year (down) 1991 Publication Allergy Abbreviated Journal Allergy  
  Volume 46 Issue 1 Pages 45-51  
  Keywords Adult; Aged; Asthma/immunology/microbiology; Basophils/immunology; Bronchoalveolar Lavage Fluid/*cytology/metabolism; Cell Count; Female; *Histamine Release; Humans; Leukocytes/*immunology; Male; Mast Cells; Middle Aged; Staphylococcal Infections/immunology; Staphylococcus aureus/*physiology; Time Factors  
  Abstract Histamine release induced by Staphylococcus aureus was examined in cells obtained by bronchoalveolar lavage (BAL) in non-atopic individuals. Approximately half of the individuals responded with mediator release to the bacterium, and the release was found to be time- and concentration dependent. No difference was found between the patients who responded and those who did not respond in regard to age, sex, smoker/non-smoker, % recovery of BAL-fluid, total cell count, differential cell counts, histamine content per mast cell, or diagnoses. Also stimulation of the BAL-cells with the calcium-ionophore A23187 resulted in histamine release. S. aureus-induced histamine release from basophils was examined in leukocyte suspensions obtained from the same individuals, and in all experiments release was found. The dose-response curves were similar to those obtained with BAL cells. The bacteria-induced mediator release from superficially lying cells in the airways epithelium might be of importance for the precipitation or exacerbation of bronchial asthma in respiratory tract infections.  
  Address Department of Pharmacology, University of Copenhagen, Denmark  
  Corporate Author Thesis  
  Impact Factor 06,028 First Author Clementsen, P. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Norn, S.  
  ISSN 0105-4538 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:1708212 Approved no  
  Call Number Serial 244  
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