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Author Bisgaard, H.; Munck, S.L.; Nielsen, J.P.; Petersen, W.; Ohlsson, S.V. url  openurl
  Title Inhaled budesonide for treatment of recurrent wheezing in early childhood Type
  Year (down) 1990 Publication Lancet Abbreviated Journal Lancet  
  Volume 336 Issue 8716 Pages 649-651  
  Keywords Administration, Inhalation; Administration, Oral; Aerosols; Budesonide; Child, Preschool; Double-Blind Method; Drug Administration Schedule; Drug Evaluation; Female; Glucocorticoids/*administration & dosage/therapeutic use; Humans; Infant; Male; Masks; Multicenter Studies as Topic; Pregnenediones/*administration & dosage/therapeutic use; Randomized Controlled Trials as Topic; Recurrence; Respiratory Sounds/*drug effects; Time Factors  
  Abstract 77 children, aged 11 to 36 months (mean 24) with moderately severe recurrent wheezing, were treated with budesonide pressurised aerosol 400 micrograms twice daily or placebo for 12 weeks in a double-blind, parallel-group trial. Aerosols were inhaled from a spacer with a facemask. Budesonide significantly improved symptom scores of wheezing, sleep disturbance, and patient happiness. The frequency of severe exacerbations that required a course of oral prednisolone was also significantly reduced. The treatment effect appeared to be fully established after 6-8 weeks and no side-effects could be ascribed to the active treatment. The findings indicate that young children below 3 years of age can inhale a pressurised aerosol from a spacer with a facemask. Use of topically active glucocorticosteroids with this simple device may reduce symptoms and distress in young children with moderately severe recurrent wheeze and dyspnoea, and possibly reduce their requirement for oral steroids.  
  Address Department of Paediatrics, University Hospital of Copenhagen, Denmark  
  Corporate Author Thesis  
  Impact Factor 45,217 First Author Bisgaard, H. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Ohlsson, S.V.  
  ISSN 0140-6736 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:1975851 Approved no  
  Call Number Serial 243  
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