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Author Clementsen, P.; Bisgaard, H.; Pedersen, M.; Permin, H.; Struve-Christensen, E.; Milman, N.; Nuchel-Petersen, B.; Norn, S. url  openurl
  Title Staphylococcus aureus and influenza A virus stimulate human bronchoalveolar cells to release histamine and leukotrienes Type Journal Article
  Year (down) 1989 Publication Agents and Actions Abbreviated Journal Agents Actions  
  Volume 27 Issue 1-2 Pages 107-109  
  Keywords Adult; Aged; Asthma/etiology/immunology; Female; *Histamine Release; Humans; In Vitro Techniques; Influenza A virus/*immunology; Leukotriene B4/secretion; Leukotrienes/*secretion; Male; Middle Aged; Respiratory System/cytology/immunology/secretion; Respiratory Tract Infections/complications/immunology; SRS-A/secretion; Staphylococcus aureus/*immunology  
  Abstract Mediator release was examined from superficially lying cells in the airway epithelium obtained by bronchoalveolar lavage (BAL) in 13 non-atopic individuals. The BAL-cells were incubated (20 min, 37 degrees C) with Staphylococcus (Staph.) aureus or with human influenza A virus Staph. aureus was found to release histamine from cells from 7 of the 13 individuals and influenza A virus in 3 of 5 persons. Furthermore, Staph, aureus stimulated the BAL-cells to release leukotriene B4 in 7 of 11 subjects, whereas no release was found by influenza A virus in 7 examined persons. When cells from 4 persons were stimulated with Staph. aureus no release of leukotriene C4 was found. The mediator release caused by bacteria and virus might be of importance for the exacerbation of bronchial asthma in upper respiratory tract infections, since histamine is assumed to increase the epithelial permeability with entrance of allergens and other insulting particles, and leukotriene B4 facilitates airway inflammation.  
  Address Dept. of Pharmacology, University of Copenhagen, Denmark  
  Corporate Author Thesis  
  Impact Factor First Author Clementsen, P. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Norn, S.  
  ISSN 0065-4299 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:2473614 Approved no  
  Call Number COPSAC @ ralfkiaerulrik @ Serial 240  
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