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Author Roorda, R.J.; Mezei, G.; Bisgaard, H.; Maden, C. url  doi
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  Title Response of preschool children with asthma symptoms to fluticasone propionate Type Journal Article
  Year (down) 2001 Publication The Journal of Allergy and Clinical Immunology Abbreviated Journal J Allergy Clin Immunol  
  Volume 108 Issue 4 Pages 540-546  
  Keywords Administration, Inhalation; Age Factors; Androstadienes/*therapeutic use; Anti-Asthmatic Agents/*therapeutic use; Asthma/*drug therapy; Child, Preschool; Double-Blind Method; Eczema; Family Characteristics; Female; Fluticasone; Humans; Infant; Male; Nebulizers and Vaporizers; Placebos; Respiratory Sounds; Rhinitis  
  Abstract BACKGROUND: Many uncertainties remain in the diagnosis and treatment of preschool children with asthma symptoms. OBJECTIVE: We sought to determine the subgroups of preschool children (aged 12-47 months) with recurrent asthma symptoms most likely to respond to inhaled fluticasone propionate (200 microg/d). METHODS: Subgroups of pooled data from 2 similar 12-week multicenter studies were analyzed. RESULTS: Children with frequent symptoms (symptoms on > or =3 days per week and a total of > or =75% days with symptoms during the 4-week run-in period; n = 169) showed a significantly greater increase in days without symptoms after fluticasone propionate treatment (0% to 45%) compared with after placebo treatment (0% to 25%, P =.005). Children with a family history of asthma (n = 213) also had a significantly greater increase in days without symptoms after fluticasone propionate (11% to 54%) compared with after placebo (7% to 35%, P =.002) and a significantly higher proportion of exacerbation-free patients (61% to 76%, P =.02). Children with less frequent symptoms, no family history of asthma, or both showed no significant treatment effect. There seemed to be no association between response to fluticasone propionate and history of rhinitis or eczema or the number of previous exacerbations. CONCLUSIONS: Children with frequent symptoms, a family history of asthma, or both showed the greatest response to fluticasone propionate treatment. These findings may help to predict treatment outcome and guide the management of preschool children with recurrent asthma symptoms.  
  Address Department of Pediatrics, Isala Klinieken, De Weezenlanden Hospital, Zwolle, The Netherlands  
  Corporate Author Thesis  
  Impact Factor 11,476 First Author Roorda, R.J. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Maden, C.  
  ISSN 0091-6749 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:11590379 Approved no  
  Call Number Serial 235  
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