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Author Kragh, M.; Larsen, J.M.; Thysen, A.H.; Rasmussen, M.A.; Wolsk, H.M.; Bisgaard, H.; Brix, S. url  doi
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  Title Divergent response profile in activated cord blood T cells from first-born child implies birth-order-associated in utero immune programming Type Journal Article
  Year (down) 2016 Publication Allergy Abbreviated Journal Allergy  
  Volume 71 Issue 3 Pages 323-332  
  Keywords T cells; immune regulation; in utero programming; neonates; parity number  
  Abstract BACKGROUND: First-born children are at higher risk of developing a range of immune-mediated diseases. The underlying mechanism of 'birth-order effects' on disease risk is largely unknown, but in utero programming of the child's immune system may play a role. OBJECTIVE: We studied the association between birth order and the functional response of stimulated cord blood T cells. METHOD: Purified cord blood T cells were polyclonally activated with anti-CD3-/anti-CD28-coated beads in a subgroup of 28 children enrolled in the COPSAC2010 birth cohort. Expression levels of seven activation markers on helper and cytotoxic T cells as well as the percentage of CD4(+) CD25(+) T cells were assessed by flow cytometry. Production of IFN-gamma, TNF-alpha, IL-17, IL-4, IL-5, IL-13, and IL-10 was measured in the supernatants. RESULTS: IL-10 secretion (P = 0.007) and CD25 expression on CD4(+) helper T cells (P = 0.0003) in the activated cord blood T cells were selectively reduced in first-born children, while the percentage of circulating CD4(+) CD25(+) cord blood T cells was independent of birth order. CONCLUSION: First-born infants display a reduced anti-inflammatory profile in T cells at birth. This possible in utero 'birth-order' T-cell programming may contribute to later development of immune-mediated diseases by increasing overall immune reactivity in first-born children as compared to younger siblings.  
  Address Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark  
  Corporate Author Thesis  
  Impact Factor 06,028 First Author Kragh, M. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Brix, S.  
  ISSN 0105-4538 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:26505887 Approved no  
  Call Number Serial 23  
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