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Author Nielsen, K.G.; Bisgaard, H. url  doi
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  Title Lung function response to cold air challenge in asthmatic and healthy children of 2-5 years of age Type Journal Article
  Year (down) 2000 Publication American Journal of Respiratory and Critical Care Medicine Abbreviated Journal Am J Respir Crit Care Med  
  Volume 161 Issue 6 Pages 1805-1809  
  Keywords Asthma/*diagnosis/drug therapy/physiopathology; Bronchial Hyperreactivity/*diagnosis/drug therapy/physiopathology; Bronchial Provocation Tests/*methods; Bronchodilator Agents/administration & dosage/adverse effects; Child, Preschool; Feasibility Studies; Female; Humans; Male; Plethysmography, Whole Body; Predictive Value of Tests; Terbutaline/administration & dosage/adverse effects  
  Abstract The aim of the study was to assess feasibility, sensitivity, specificity, predictive value, and repeatability of cold, dry air challenge (CACh) as a diagnostic test for asthma in young children 2 to 5 yr of age. Response to a 4-min single-step isocapnic CACh was measured in 38 asthmatics and 29 control subjects. Specific airway resistance (sRaw) by whole body plethysmography was the primary outcome. In addition, lung function was measured as respiratory resistance by the interrupter technique (Rint) and respiratory resistance and reactance at 5 Hz (Rrs5, Xrs5) by the impulse oscillation technique. At baseline, lung function measures differed significantly between asthmatics and healthy control subjects. CACh was readily performed in young children. Response was expressed as change from baseline in numbers of within-subject standard deviation (SDw). Hyperresponsiveness defined as change in lung function of more than 3 SDw was detected by sRaw in 26 of 38 asthmatics versus 2 of 29 control subjects, by Rint in 12 of 38 asthmatics versus 1 of 29 control subjects, by Xrs5 in 9 of 38 asthmatics versus zero of 29 control subjects and by Rrs5 in 7 of 38 asthmatics versus 1 of 29 control subjects. Thus sRaw had the highest sensitivity (68%). Specificity ranged from 93 to 100%. The correlation coefficient between sRaw responses to CACh repeated within 8 wk was 96%. In conclusion, CACh is feasible in young children age 2 to 5 yr. Whole body plethysmography (sRaw) was superior in separating asthmatics from healthy control subjects. Change in sRaw in response to CACh may be used as a diagnostic test for asthma in young children.  
  Address Department of Pediatrics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark  
  Corporate Author Thesis  
  Impact Factor 12,996 First Author Nielsen, K.G. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Bisgaard, H.  
  ISSN 1073-449X ISBN Medium  
  Area Expedition Conference  
  Notes PMID:10852748 Approved no  
  Call Number Serial 221  
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