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Author Klug, B.; Bisgaard, H. url  openurl
  Title Lung function and short-term outcome in young asthmatic children Type Journal Article
  Year (down) 1999 Publication The European Respiratory Journal Abbreviated Journal Eur Respir J  
  Volume 14 Issue 5 Pages 1185-1189  
  Keywords Anti-Asthmatic Agents/administration & dosage; Asthma/diagnosis/drug therapy/*physiopathology; Child, Preschool; Cross-Sectional Studies; Female; Follow-Up Studies; Humans; Lung/*physiopathology; Male; Respiratory Function Tests; Risk Factors; Time Factors; Treatment Outcome  
  Abstract The aims of this study were to investigate lung function in 2-5-yr-old stable asthmatic children consecutively referred from general practitioners and to analyse the outcome on the basis of their requirement for antiasthmatic treatment and symptoms after 1.6-4.5 yrs. Lung function was measured in 110 children with a mean+/-SD age of 3.8+/-1.0 yrs using the interruptor technique (resistance assessed using the interruptor technique (Rint)), whole body plethysmography (specific airway resistance (sRaw) and respiratory resistance (Rrs,5)and reactance at 5 Hz (Xrs,5) using the impulse oscillation technique. Rint, sRaw, Xrs,5 and Rrs,5 were suggestive of impaired lung function in 44%, 14%, 11% and 7.5% of the children, respectively, with a predominance of children aged 2-3 yrs. Sixty-five per cent were treated with inhaled steroids, and 35% were treated only with beta2-agonists as needed; lung function was not significantly different between these two groups. Outcome after 2.9+/-0.7 yrs was not significantly different between children with Rint measurements above and those children with Rint measurements within the reference range at enrolment. Of these children, 58 and 59% were currently on antiasthmatic treatment, and 40% and 49% had current symptoms, respectively. Impairment of lung function may be a common finding in stable young asthmatic children, but apparently this is not a risk factor for persistence of asthmatic symptoms.  
  Address Dept of Pediatrics 5003, National University Hospital, Rigshospitalet, Copenhagen, Denmark  
  Corporate Author Thesis  
  Impact Factor 07,636 First Author Klug, B. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Bisgaard, H.  
  ISSN 0903-1936 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:10596711 Approved no  
  Call Number Serial 216  
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