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Author Bisgaard, H.; Loland, L.; Oj, J.A. url  doi
  Title NO in exhaled air of asthmatic children is reduced by the leukotriene receptor antagonist montelukast Type Journal Article
  Year (down) 1999 Publication American Journal of Respiratory and Critical Care Medicine Abbreviated Journal Am J Respir Crit Care Med  
  Volume 160 Issue 4 Pages 1227-1231  
  Keywords Acetates/*therapeutic use; Adolescent; Anti-Asthmatic Agents/*therapeutic use; Asthma/diagnosis/*drug therapy/physiopathology; *Breath Tests; Child; Cross-Over Studies; Double-Blind Method; Forced Expiratory Volume; Glucocorticoids/therapeutic use; Humans; Leukotriene Antagonists/*therapeutic use; Maximal Midexpiratory Flow Rate; Nitric Oxide/*analysis; Quinolines/*therapeutic use; Spirometry  
  Abstract Nitric oxide in exhaled air (FENO) is increased in asthmatic children, probably reflecting aspects of airway inflammation. We have studied the effect of the leukotriene receptor antagonist (LTRA) montelukast on FENO with a view to elucidate potential anti-inflammatory properties of LTRAs. Twenty-six asthmatic children 6 to 15 yr of age completed a double-blind crossover trial of 2 wk of treatment with 5 mg montelukast once daily versus placebo. FENO was measured during single-breath exhalation at a constant flow rate of 0.1 to 0.13 L/s against a resistance of 10 kPa/L/s. Eleven children were receiving maintenance treatment with inhaled steroids during the study (mean daily dose, 273 microgram), whereas the other 15 used only inhaled beta(2)-agonists as required. The within-subject coefficient of variation of FENO over a 2-wk interval for the 26 children was 38%. FENO was significantly reduced by 20% after the 2-wk treatment with montelukast as compared with placebo as well as compared with baseline. This effect occurred rapidly with a 15% fall in FENO within 2 d. The effect of montelukast on FENO was independent of concurrent steroid treatment. The effect on FENO is probably not caused by bronchodilatation since FENO increased significantly after inhalation of terbutaline. In conclusion, FENO in asthmatic children was significantly decreased from montelukast, which corroborates anti- inflammatory properties of LTRA.  
  Address Department of Paediatrics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. Bisgaard@RH.DK  
  Corporate Author Thesis  
  Impact Factor 12,996 First Author Bisgaard, H. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Oj, J.A.  
  ISSN 1073-449X ISBN Medium  
  Area Expedition Conference  
  Notes PMID:10508811 Approved no  
  Call Number Serial 215  
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