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Author Fleming, L.; Murray, C.; Bansal, A.T.; Hashimoto, S.; Bisgaard, H.; Bush, A.; Frey, U.; Hedlin, G.; Singer, F.; van Aalderen, W.M.; Vissing, N.H.; Zolkipli, Z.; Selby, A.; Fowler, S.; Shaw, D.; Chung, K.F.; Sousa, A.R.; Wagers, S.; Corfield, J.; Pandis, I.; Rowe, A.; Formaggio, E.; Sterk, P.J.; Roberts, G. url  doi
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  Title The burden of severe asthma in childhood and adolescence: results from the paediatric U-BIOPRED cohorts Type Journal Article
  Year (down) 2015 Publication The European Respiratory Journal Abbreviated Journal Eur Respir J  
  Volume 46 Issue 5 Pages 1322-1333  
  Keywords  
  Abstract U-BIOPRED aims to characterise paediatric and adult severe asthma using conventional and innovative systems biology approaches. A total of 99 school-age children with severe asthma and 81 preschoolers with severe wheeze were compared with 49 school-age children with mild/moderate asthma and 53 preschoolers with mild/moderate wheeze in a cross-sectional study. Despite high-dose treatment, the severe cohorts had more severe exacerbations compared with the mild/moderate ones (annual medians: school-aged 3.0 versus 1.1, preschool 3.9 versus 1.8; p<0.001). Exhaled tobacco exposure was common in the severe wheeze cohort. Almost all participants in each cohort were atopic and had a normal body mass index. Asthma-related quality of life, as assessed by the Paediatric Asthma Quality of Life Questionnaire (PAQLQ) and the Paediatric Asthma Caregiver's Quality of Life Questionnaire (PACQLQ), was worse in the severe cohorts (mean+/-se school-age PAQLQ: 4.77+/-0.15 versus 5.80+/-0.19; preschool PACQLQ: 4.27+/-0.18 versus 6.04+/-0.18; both p</=0.001); however, mild/moderate cohorts also had significant morbidity. Impaired quality of life was associated with poor control and airway obstruction. Otherwise, the severe and mild/moderate cohorts were clinically very similar. Children with severe preschool wheeze or severe asthma are usually atopic and have impaired quality of life that is associated with poor control and airflow limitation: a very different phenotype from adult severe asthma. In-depth phenotyping of these children, integrating clinical data with high-dimensional biomarkers, may help to improve and tailor their clinical management.  
  Address NIHR Southampton Respiratory Biomedical Research Unit, Clinical and Experimental Sciences and Human Development and Health, Southampton, UK Faculty of Medicine, University of Southampton, Southampton, UK The David Hide Asthma and Allergy Research Centre, St Mary's Hospital, Isle of Wight, UK g.c.roberts@soton.ac.uk  
  Corporate Author U-BIOPRED Study Group Thesis  
  Impact Factor 07,636 First Author Fleming, L. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Roberts, G.  
  ISSN 0903-1936 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:26405287 Approved no  
  Call Number Serial 21  
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