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Author Borum, S.; Nielsen, K.; Bisgaard, H.; Mygind, N. url  openurl
  Title Experimentally induced nasal hypersecretion does not reduce the efficacy of intranasal levocabastine Type Journal Article
  Year (down) 1998 Publication Rhinology Abbreviated Journal Rhinology  
  Volume 36 Issue 4 Pages 153-155  
  Keywords Administration, Intranasal; Adult; Analysis of Variance; Double-Blind Method; Female; Histamine/administration & dosage; Histamine H1 Antagonists/administration & dosage/*therapeutic use; Humans; Male; Methacholine Chloride/administration & dosage; Nasal Lavage Fluid; Nasal Mucosa/drug effects/*secretion; Nasal Provocation Tests; Piperidines/administration & dosage/*therapeutic use; Rhinitis/*drug therapy; Sneezing; Statistics, Nonparametric  
  Abstract In allergic rhinitis, a nasal H1-antihistamine spray seems to be well suited for usage on an as-needed basis, because it has a quick onset of action, and many patients prefer to take medicine only when they have symptoms. It is a prerequisite, however, that nasal hypersecretion during a rhinitis episode does not significantly reduce the efficacy of intranasal treatment by washing away the drug before it reaches the H1-histamine receptors. In order to investigate this problem, we have induced nasal hypersecretion with a methacholine challenge in one experiment and in four experiments we have washed the nasal cavities 0.5 min. before, 5 min. before, 0.5 min. after and 5 min. after intranasal use of the H1-antagonist, levocabastine. The symptom response to a subsequent histamine challenge was used as the effect parameter. Levocabastine reduced the number of histamine-induced sneezes with 81% (p < 0.0001) and the secretion weight with 62% (p < 0.001) compared with placebo. Neither methacholine-induced hypersecretion nor washing the nose with saline reduced the efficacy of the antihistamine spray. We conclude that experimentally induced nasal hypersecretion does not reduce the efficacy of the antihistamine spray, and probably the same applies to rhinorrhea during an acute episode of allergic rhinitis.  
  Address Department of Pediatrics, National University Hospital, Copenhagen, Denmark  
  Corporate Author Thesis  
  Impact Factor 03,761 First Author Borum, S. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Mygind, N.  
  ISSN 0300-0729 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:9923056 Approved no  
  Call Number Serial 205  
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