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Author Pedersen, W.; Hjuler, I.; Bisgaard, H.; Mygind, N. url  openurl
  Title Nasal inhalation of budesonide from a spacer in children with perennial rhinitis and asthma Type
  Year (down) 1998 Publication Allergy Abbreviated Journal Allergy  
  Volume 53 Issue 4 Pages 383-387  
  Keywords Administration, Inhalation; Administration, Intranasal; Adolescent; Anti-Inflammatory Agents/*administration & dosage; Asthma/*drug therapy; Budesonide/*administration & dosage; Child; Cross-Over Studies; Double-Blind Method; Female; Glucocorticoids; Humans; Male; Rhinitis, Allergic, Perennial/*drug therapy  
  Abstract The standard treatment of allergic rhinitis and asthma consists of topical corticosteroids administered intranasally and inhaled through the mouth. Although this therapy is highly effective, and side-effects are few and mild, it may be possible further to improve the therapeutic index and patient compliance with the treatment. In the present study, we evaluated a nasal inhalation system used for the simultaneous treatment of rhinitis and asthma. In principle, it results in an airway deposition of the corticosteroid similar to that of inhaled allergens. Twenty-four children with perennial rhinitis and asthma inhaled budesonide through the nose from a pressurized aerosol, attached to a spacer device, in a double-blind, placebo-controlled, crossover study. Compared with placebo, budesonide treatment resulted in a significant reduction of nasal symptoms (P<0.01) and of asthma symptoms (P<0.05), and in an increase of nasal peak inspiratory flow (P < 0.001) and of oral peak expiratory flow (P=0.01). There were no differences between budesonide and placebo in local side-effects, such as dry nose, nosebleed, and hoarseness. We conclude that nasal inhalation of a corticosteroid from a spacer offers a simple and effective treatment for both rhinitis and asthma in children, but it is an open question whether the nasal inhalation system can improve the ratio of antirhinitis/antiasthma effects to side-effects.  
  Address Department of Paediatrics, Gentofte Hospital, Hellerup, Denmark  
  Corporate Author Thesis  
  Impact Factor 06,028 First Author Pedersen, W. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Mygind, N.  
  ISSN 0105-4538 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:9574880 Approved no  
  Call Number Serial 201  
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