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Author Bisgaard, H. url  doi
  Title Automatic actuation of a dry powder inhaler into a nonelectrostatic spacer Type Journal Article
  Year (down) 1998 Publication American Journal of Respiratory and Critical Care Medicine Abbreviated Journal Am J Respir Crit Care Med  
  Volume 157 Issue 2 Pages 518-521  
  Keywords Budesonide/administration & dosage; Child, Preschool; *Drug Delivery Systems; Equipment Design; Evaluation Studies as Topic; Half-Life; Humans; Medical Illustration; *Nebulizers and Vaporizers; Particle Size; Powders/*administration & dosage  
  Abstract This article describes a new “automatic spacer” device, which has been developed to improve the delivery of inhaled medication to young children. In the device, a dry powder inhaler (DPI) is mechanically actuated into a nonelectrostatic spacer, producing an aerosol cloud of fine drug particles (aerodynamic diameter, < 4.7 microm) with a long half-life. The new device combines the principal advantages of the conventional spacer and the DPI. It has the potential to provide a high ratio between lung dose and pharyngeal dose, without need for coordination or forced inhalation, and it avoids exposure of the patient to the additives and propellants used in pressurized metered dose inhalers. Studies with the prototype device show a high yield of fine drug particles in the aerosol (mass median aerodynamic diameter, 2.8 microm), a high repeatability of drug delivery owing to the mechanical nature of the actuation (relative standard deviation, 12%), and a prolonged residence time of the fine particle aerosol (half-life of the fallout of the fine particles, 82 s). These features should prove advantageous in the treatment of young children with inhaled medication.  
  Address Pulmonary Service, Department of Pediatrics, Rigshospitalet, National University Hospital, Copenhagen, Denmark. Bisgaard@RH.DK  
  Corporate Author Thesis  
  Impact Factor 12,996 First Author Bisgaard, H. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Bisgaard, H.  
  ISSN 1073-449X ISBN Medium  
  Area Expedition Conference  
  Notes PMID:9476867 Approved no  
  Call Number Serial 200  
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