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Author Loisel, D.A.; Du, G.; Ahluwalia, T.S.; Tisler, C.J.; Evans, M.D.; Myers, R.A.; Gangnon, R.E.; Kreiner-Moller, E.; Bonnelykke, K.; Bisgaard, H.; Jackson, D.J.; Lemanske, R.F.J.; Nicolae, D.L.; Gern, J.E.; Ober, C. url  doi
  Title Genetic associations with viral respiratory illnesses and asthma control in children Type Journal Article
  Year (down) 2016 Publication Clinical and Experimental Allergy Abbreviated Journal Clin Exp Allergy  
  Volume 46 Issue 1 Pages 112-124  
  Keywords allergic sensitization; asthma; children; cold symptoms; genetic association; human rhinovirus; viral respiratory illness; wheezing  
  Abstract BACKGROUND: Viral respiratory infections can cause acute wheezing illnesses in children and exacerbations of asthma. OBJECTIVE: We sought to identify variation in genes with known antiviral and pro-inflammatory functions to identify specific associations with more severe viral respiratory illnesses and the risk of virus-induced exacerbations during the peak fall season. METHODS: The associations between genetic variation at 326 SNPs in 63 candidate genes and 10 phenotypes related to viral respiratory infection and asthma control were examined in 226 children enrolled in the RhinoGen study. Replication of asthma control phenotypes was performed in 2128 children in the Copenhagen Prospective Study on Asthma in Childhood (COPSAC). Significant associations in RhinoGen were further validated using virus-induced wheezing illness and asthma phenotypes in an independent sample of 122 children enrolled in the Childhood Origins of Asthma (COAST) birth cohort study. RESULTS: A significant excess of P values smaller than 0.05 was observed in the analysis of the 10 RhinoGen phenotypes. Polymorphisms in 12 genes were significantly associated with variation in the four phenotypes showing a significant enrichment of small P values. Six of those genes (STAT4, JAK2, MX1, VDR, DDX58, and EIF2AK2) also showed significant associations with asthma exacerbations in the COPSAC study or with asthma or virus-induced wheezing phenotypes in the COAST study. CONCLUSIONS: We identified genetic factors contributing to individual differences in childhood viral respiratory illnesses and virus-induced exacerbations of asthma. Defining mechanisms of these associations may provide insight into the pathogenesis of viral respiratory infections and virus-induced exacerbations of asthma.  
  Address Department of Human Genetics, University of Chicago, Chicago, IL, USA  
  Corporate Author Thesis  
  Impact Factor 04,769 First Author Loisel, D.A. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Ober, C.  
  ISSN 0954-7894 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:26399222; PMCID:PMC4715666 Approved no  
  Call Number Serial 20  
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