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Author Nielsen, K.G.; Auk, I.L.; Bojsen, K.; Ifversen, M.; Klug, B.; Bisgaard, H. url  openurl
  Title Clinical effect of Diskus dry-powder inhaler at low and high inspiratory flow-rates in asthmatic children Type
  Year (down) 1998 Publication The European Respiratory Journal Abbreviated Journal Eur Respir J  
  Volume 11 Issue 2 Pages 350-354  
  Keywords Adolescent; Albuterol/administration & dosage/*analogs & derivatives/therapeutic use; Asthma, Exercise-Induced/*drug therapy/*physiopathology; Bronchoconstriction/drug effects/physiology; Bronchodilator Agents/administration & dosage/therapeutic use; Child; Cross-Over Studies; Double-Blind Method; Exercise; Female; Forced Expiratory Volume/physiology; Humans; Male; *Nebulizers and Vaporizers; Powders; Pulmonary Ventilation/*physiology; Salmeterol Xinafoate  
  Abstract In vitro studies with the Diskus inhaler at low and high flow rates show consistent doses of drug as fine particles <4.7 microm. The present study was designed to ascertain whether this in vitro flow independency translates into flow-independent clinical effect when the device is used by patients at low (30 L x min[-1]) and high (90 L x min[-1]) flow rates. A pilot study in 129 children aged 3-10 yrs demonstrated that 99% of children of 3 yrs and above can generate a flow > or = 30 L x min(-1) through the device, while 26% performed > or = 90 L x min(-1). Eighteen children aged 8-15 yrs with exercise induced asthma inhaled placebo or salmeterol 50 microg at either 30 L x min(-1) or 90 L x min(-1). Exercise challenges were carried out 1 h and 12 h after dosing. The maximum percentage fall in forced expiratory volume in one second (FEVI) after exercise 12 h after treatment was significantly less after salmeterol at either flow rates as compared to placebo. There was no significant difference in the protection from salmeterol on the day of low-flow inhalation versus the day of high-flow inhalation. Consistent in vitro fine particle dosing from the Diskus inhaler translates into a consistent clinical effect at low and high flow rates in children.  
  Address Dept of Paediatrics, National University Hospital, Copenhagen, Denmark  
  Corporate Author Thesis  
  Impact Factor 07,636 First Author Nielsen, K.G. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Bisgaard, H.  
  ISSN 0903-1936 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:9551737 Approved no  
  Call Number Serial 199  
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