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Author Lauritzen, L.; Halkjaer, L.B.; Mikkelsen, T.B.; Olsen, S.F.; Michaelsen, K.F.; Loland, L.; Bisgaard, H. url  openurl
  Title Fatty acid composition of human milk in atopic Danish mothers Type Journal Article
  Year (down) 2006 Publication The American Journal of Clinical Nutrition Abbreviated Journal Am J Clin Nutr  
  Volume 84 Issue 1 Pages 190-196  
  Keywords Adult; Asthma/*metabolism; Cohort Studies; Denmark; Dermatitis, Atopic/*metabolism; Diet; Fatty Acids, Omega-3/analysis; Fatty Acids, Omega-6/analysis; Fatty Acids, Unsaturated/*analysis/metabolism; Female; Humans; Infant, Newborn; Lactation/*metabolism; Milk, Human/*chemistry; Prospective Studies; Surveys and Questionnaires  
  Abstract BACKGROUND: Atopic dermatitis has been related to a disturbed metabolism of polyunsaturated fatty acids (PUFAs). OBJECTIVE: We tested whether the PUFA composition of breast milk differs significantly between mothers with atopic dermatitis, mothers with other types of atopy, and nonatopic mothers. We also investigated whether differences in diet can explain possible observed differences. DESIGN: Mothers with current or previous asthma (n = 396) were divided into 3 groups according to history of atopic dermatitis and allergic rhinitis. Breast-milk samples were collected from 314 women approximately 3 wk after delivery. The habitual diet of the women was assessed with food-frequency questionnaires in the 25th week of gestation (n = 207). Breast-milk samples and simultaneous dietary data from 14 nonatopic mothers were used for comparison. RESULTS: Compared with the milk of nonatopic mothers, that of atopic mothers had significantly higher concentrations of 22:5n-6 and lower concentrations of 20:5n-3; moreover, 20:4n-6/20:5n-3, 22:5n-6/22:6n-3, and long-chain n-3 PUFA/18:3n-3 were shifted toward n-6 PUFA and 18:3n-3 in nonatopic and atopic mothers, respectively. No differences in breast-milk PUFA composition were evident between the subject groups. The diets of the groups differed only slightly with respect to protein intake. However, the PUFA composition of the breast milk was associated with diet and time of milk sampling, and the above difference in milk PUFAs disappeared when those factors were taken into account. CONCLUSION: Our data do not support the possibility that the fatty acid composition of breast milk is affected by atopic dermatitis or atopy in general, because most differences in breast-milk PUFA composition appear to be explained by the diet.  
  Address Department of Human Nutrition, Center for Advanced Food Studies, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark.  
  Corporate Author Thesis  
  Impact Factor 06,770 First Author Lauritzen, L. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Bisgaard, H.  
  ISSN 0002-9165 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:16825695 Approved no  
  Call Number Serial 196  
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