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Author Halkjaer, L.B.; Loland, L.; Buchvald, F.F.; Agner, T.; Skov, L.; Strand, M.; Bisgaard, H. url  doi
  Title Development of atopic dermatitis during the first 3 years of life: the Copenhagen prospective study on asthma in childhood cohort study in high-risk children Type Journal Article
  Year (down) 2006 Publication Archives of Dermatology Abbreviated Journal Arch Dermatol  
  Volume 142 Issue 5 Pages 561-566  
  Keywords Age Factors; Asthma/complications; Child, Preschool; Cohort Studies; Denmark/epidemiology; Dermatitis, Atopic/complications/*epidemiology/physiopathology; Disease-Free Survival; Female; Humans; Infant; Infant, Newborn; Longitudinal Studies; Male; Prevalence; Prospective Studies; Risk Factors; Severity of Illness Index; Sex Factors  
  Abstract OBJECTIVES: To describe the development of atopic dermatitis (AD) during the first 3 years of life and identify the localization of the early skin lesions that predicts the development of AD. DESIGN: Prospective, longitudinal, birth cohort study of children born to mothers with a history of asthma, followed up for 3 years with scheduled visits every 6 months as well as visits for onset or acute exacerbations of skin symptoms. SETTING: The cohort was recruited from greater Copenhagen, Denmark, and followed up at a clinical research unit, which controlled all diagnoses and treatment of skin diseases. PARTICIPANTS: A total of 411 infants were enrolled in the cohort; 55 had incomplete follow-up and were excluded from certain analyses. MAIN OUTCOME MEASURES: Atopic dermatitis was defined based on the criteria of Hanifin and Rajka, and severity was assessed by the SCORAD (Scoring Atopic Dermatitis) index. Predictive odds ratios of early skin lesions for those who developed AD vs those who did not were calculated. RESULTS: The cumulative incidence of AD by age 3 years was 44% (155/356). The prevalence rate peaked at age 2 years for boys and at age 2.5 years for girls, but there were no other sex differences in the proportion of children developing AD. Skin involvement in infants with AD was found to begin at the scalp, forehead, ear, and neck in a balaclava-like pattern and continue to the extensor sides and trunk, finally affecting the flexor sides of the extremities. Early skin lesions of arms and joints best predicted AD at age 3 years. CONCLUSIONS: Atopic dermatitis begins at the scalp, forehead, ear, and neck in a balaclava-like pattern. Eczema at the arms and joints provides the highest predictive value for the development of AD at age 3 years. This may be used for early prediction and intervention of AD.  
  Address Danish Pediatric Asthma Centre, Department of Pediatrics, Copenhagen University Hospital, Gentofte, Denmark  
  Corporate Author Thesis  
  Impact Factor 04,789 First Author Halkjaer, L.B. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Bisgaard, H.  
  ISSN 0003-987X ISBN Medium  
  Area Expedition Conference  
  Notes PMID:16702493 Approved no  
  Call Number Serial 192  
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