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Author Loland, L.; Buchvald, F.F.; Halkjaer, L.B.; Anhoj, J.; Hall, G.L.; Persson, T.; Krause, T.G.; Bisgaard, H. url  doi
  Title Sensitivity of bronchial responsiveness measurements in young infants Type Journal Article
  Year (down) 2006 Publication Chest Abbreviated Journal Chest  
  Volume 129 Issue 3 Pages 669-675  
  Keywords Asthma/diagnosis/*physiopathology; Blood Gas Monitoring, Transcutaneous; *Bronchial Provocation Tests; Bronchoconstrictor Agents/pharmacology; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; Infant; Male; Methacholine Chloride/pharmacology; Tidal Volume  
  Abstract OBJECTIVES: There is limited evidence on the preferred methods for evaluating lung function in infancy. The objective of this study was to compare sensitivity and repeatability of indexes of lung function in young infants during induced airway obstruction. METHODS: The study population consisted of 402 infants (median age, 6 weeks). Forced flow-volume measurements were obtained by the raised volume rapid thoracoabdominal compression technique and were compared with indexes of tidal breathing, measurements of transcutaneous oxygen (Ptco(2)), and auscultation during methacholine challenge testing. RESULTS: Ptco(2) was the most sensitive parameter to detect increasing airway obstruction during methacholine challenge, followed by forced expiratory volume at 0.5 s (FEV(0.5)). Both were superior to other indexes of forced spirometry as well as tidal breathing indexes and auscultation. Coefficients of variations for Ptco(2) and FEV(0.5) were 4% and 7%, respectively. CONCLUSIONS: Ptco(2) and FEV(0.5) are the most sensitive parameters for measurement of bronchial responsiveness in young infants. Measurements of baseline lung function should preferably be made using FEV(0.5.) Measurements of bronchial responsiveness are best assessed using Ptco(2), which may be performed in nonsedated infants and improve feasibility of future studies on lung function in infancy.  
  Address Danish Pediatric Asthma Center, Department of Pediatrics, Copenhagen University Hospital, Gentofte, Niels Andersens Vej 65, DK-2900 Hellerup, Denmark  
  Corporate Author Thesis  
  Impact Factor 07,483 First Author Loland, L. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Bisgaard, H.  
  ISSN 0012-3692 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:16537866 Approved no  
  Call Number Serial 190  
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