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Author Nielsen, K.G.; Bisgaard, H. url  doi
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  Title Cold air challenge and specific airway resistance in preschool children Type Journal Article
  Year (down) 2005 Publication Paediatric Respiratory Reviews Abbreviated Journal Paediatr Respir Rev  
  Volume 6 Issue 4 Pages 255-266  
  Keywords *Airway Resistance; Asthma/drug therapy/physiopathology; Bronchial Provocation Tests/instrumentation/*methods; Child, Preschool; Humans; Plethysmography; Quality Control; Respiratory Tract Diseases/physiopathology; Sensitivity and Specificity  
  Abstract Important asthma outcomes such as lung function and bronchial hyperresponsiveness are probably determined in early childhood. Early and longitudinal objective assessment of lung function and bronchial hyperresponsiveness is necessary to enable early diagnosis, monitor intervention and improve prognosis in preschool children. Cold air challenge and plethysmographic measurement of specific airway resistance (sRaw) are feasible candidate methods for diagnosis, clinical monitoring and research during this critical period of lung growth and development. Methodology and practical aspects of cold air challenge and assessment of sRaw in preschool children are reviewed. Reference values are provided for sRaw and have allowed discrimination between health and respiratory disease, both in cross-sectional and longitudinal studies. Bronchial hyperresponsiveness can be determined with acceptable repeatability and provides good discrimination between asthmatics and healthy. The effects of classic anti-asthmatic therapies have also been documented with these techniques. The need for further standardisation and improvement of these methods and future perspectives are outlined.  
  Address Pediatric Pulmonary Service, Pediatric Clinic I, Juliane Marie Centre, Rigshospitalet, Copenhagen University Hospital, Denmark. kgn@dadlnet.dk  
  Corporate Author Thesis  
  Impact Factor 02,196 First Author Nielsen, K.G. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Bisgaard, H.  
  ISSN 1526-0542 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:16298308 Approved no  
  Call Number Serial 188  
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