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Author Buchvald, F.; Hermansen, M.N.; Nielsen, K.G.; Bisgaard, H. url  doi
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  Title Exhaled nitric oxide predicts exercise-induced bronchoconstriction in asthmatic school children Type Journal Article
  Year (down) 2005 Publication Chest Abbreviated Journal Chest  
  Volume 128 Issue 4 Pages 1964-1967  
  Keywords Adolescent; Asthma, Exercise-Induced/*physiopathology; *Breath Tests; Bronchoconstriction; Child; Exhalation; Female; Humans; Male; Nitric Oxide/*analysis; Outpatients  
  Abstract BACKGROUND: Exercise-induced bronchoconstriction (EIB) is of particular importance in children with asthma. It is an important measure of asthma control and should be monitored by exercise testing. However, exercise testing puts a large demand on health-care resources and is therefore not widely used in routine monitoring of pediatric asthma control. The fractional concentration of exhaled nitric oxide (FeNO) also reflects uncontrolled asthma. We hypothesized that FeNO may be used for prescreening of asthmatic children to exclude those with good asthma control unlikely to have EIB, thereby reducing the need for exercise testing. OBJECTIVE: The aim of this study was to estimate the value of FeNO as a predictor of EIB in asthmatic children. METHODS: Stable outpatient asthmatic school children performed standard exercise challenge tests and measurement of FeNO. RESULTS: FeNO and response to a standardized submaximal exercise test on the treadmill were measured in 111 school children with asthma. EIB could be excluded with a probability of 90% in asthmatic children with FeNO levels < 20 parts per billion (ppb) without current inhaled corticosteroid treatment, and < 12 ppb in children with current inhaled corticosteroid treatment. CONCLUSION: Measurement of FeNO is a simple, and time- and resource-efficient tool that may be used to screen for EIB testing and therefore optimizes the resources for exercise testing in pediatric asthma monitoring.  
  Address Danish Pediatric Asthma Centre, Department of Pediatrics, Copenhagen University Hospital, DK-2900 Gentofte, Niels Andersensvej 79, 2900 Hellerup, Denmark  
  Corporate Author Thesis  
  Impact Factor 07,483 First Author Buchvald, F. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Bisgaard, H.  
  ISSN 0012-3692 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:16236842 Approved no  
  Call Number Serial 187  
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