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Author Buchvald, F.; Baraldi, E.; Carraro, S.; Gaston, B.; De Jongste, J.; Pijnenburg, M.W.H.; Silkoff, P.E.; Bisgaard, H. url  doi
  Title Measurements of exhaled nitric oxide in healthy subjects age 4 to 17 years Type Journal Article
  Year (down) 2005 Publication The Journal of Allergy and Clinical Immunology Abbreviated Journal J Allergy Clin Immunol  
  Volume 115 Issue 6 Pages 1130-1136  
  Keywords Adolescent; Age Factors; Asthma/*diagnosis/ethnology; Breath Tests/instrumentation/*methods; Child; Child, Preschool; Conjunctivitis/diagnosis; Ethnic Groups; Europe; Exhalation; Feasibility Studies; Female; Humans; Male; Nitric Oxide/*analysis/standards; Reference Values; Reproducibility of Results; Rhinitis/diagnosis; Sex Factors; Surveys and Questionnaires; United States  
  Abstract BACKGROUND: Fractional exhaled nitric oxide (FE NO ) is used in monitoring of asthma. OBJECTIVES: The aim of this multicenter study was to establish normal values of FE NO and assess feasibility in children with a standardized method and equipment approved for clinical use. METHODS: FE NO was measured in healthy subjects of 4 to 17 years according to American Thoracic Society guidelines (single breath online, exhalation flow 50 mL/s) with a chemiluminescence analyzer (NIOX Exhaled Nitric Oxide Monitoring System, Aerocrine, Sweden) in 3 European and 2 US centers. Each child performed 3 acceptable nitric oxide measurements within 6 attempts and completed an extended International Study of Asthma and Allergy in Children questionnaire. RESULTS: Measurement of FE NO was attempted in 522 children. Four hundred five children completed the study according to the protocol. Geometric mean FE NO in 405 children was 9.7 ppb, and the upper 95% confidence limit was 25.2 ppb. FE NO increased significantly with age, and higher FE NO was seen in children with self-reported rhinitis/conjunctivitis or hay fever. The success rate was age-dependent and improved from 40% in the children 4 years old to almost 100% from the age of 10 years. The repeatability of 3 approved measurements was 1.6 ppb (95% CI, 1.49-1.64 ppb). CONCLUSION: FE NO in healthy children is below 15 to 25 ppb depending on age and self-reported atopy. Measurement of FE NO by NIOX is simple and safe and has a good repeatability. Feasibility depends on age and may be difficult in the preschool child.  
  Address The Copenhagen Studies of Asthma in Childhood Research Clinic, Copenhagen University Hospital, Gentofte, Denmark  
  Corporate Author Thesis  
  Impact Factor 11,476 First Author Buchvald, F. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Bisgaard, H.  
  ISSN 0091-6749 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:15940124 Approved no  
  Call Number Serial 183  
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