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Author Nielsen, K.G.; Bisgaard, H. url  doi
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  Title Hyperventilation with cold versus dry air in 2- to 5-year-old children with asthma Type
  Year (down) 2005 Publication American Journal of Respiratory and Critical Care Medicine Abbreviated Journal Am J Respir Crit Care Med  
  Volume 171 Issue 3 Pages 238-241  
  Keywords Air; Airway Resistance/physiology; Asthma/*diagnosis/physiopathology; Bronchial Hyperreactivity/*diagnosis/physiopathology; Bronchial Provocation Tests/*methods; Bronchoconstriction/physiology; Child, Preschool; *Cold Temperature; Female; Humans; Hyperventilation/*physiopathology; Male; Plethysmography, Whole Body  
  Abstract Cold air challenge (CACh) has been shown to discriminate between children with asthma and healthy young children. Hyperventilation with dry room-temperature air is a simplified alternative. We compared responsiveness in young children with asthma between two standardized, single-step protocols: dry air challenge (DACh) performed as 6 minutes of eucapnic hyperventilation with dry room-temperature air and CACh as 4 minutes of hyperventilation. Response was measured as specific airway resistance by whole-body plethysmography and expressed as change from baseline in numbers of within-subject SDs (SDw). The challenge sequence was randomly assigned. A comparator challenge was performed 1 hour later if the first challenge gave a change of 3 SDw or more. Forty 2- to 5-year-old children with asthma were included. Responsiveness to cold versus dry air showed significant, but weak, correlation (r(2) = 0.34, p < 0.0001), but responsiveness to CACh exceeded DACh (7.6 vs. 5.4 SDw, p < 0.02). CACh seemed to induce reduction in response to the following DACh (p < 0.01), whereas no such reduction was seen after DACh. CONCLUSION: Responsiveness to CACh exceeded responsiveness to DACh, and CACh seemed to induce refractoriness in contrast to DACh, probably because of the additional stimulus from airway cooling. This finding suggests CACh as the preferred method of challenge.  
  Address Department of Pediatrics, Pulmonary Service, Copenhagen University Hospital, Rigshospitalet DK-2100, Copenhagen, Denmark. kgn@dadlnet.dk  
  Corporate Author Thesis  
  Impact Factor 12,996 First Author Nielsen, K.G. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Bisgaard, H.  
  ISSN 1073-449X ISBN Medium  
  Area Expedition Conference  
  Notes PMID:15542794 Approved no  
  Call Number Serial 179  
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