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Author Nielsen, K.G.; Pressler, T.; Klug, B.; Koch, C.; Bisgaard, H. url  doi
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  Title Serial lung function and responsiveness in cystic fibrosis during early childhood Type Journal Article
  Year (down) 2004 Publication American Journal of Respiratory and Critical Care Medicine Abbreviated Journal Am J Respir Crit Care Med  
  Volume 169 Issue 11 Pages 1209-1216  
  Keywords Airway Resistance/drug effects/physiology; Bronchial Provocation Tests; Bronchodilator Agents/therapeutic use; Child; Child Welfare; Child, Preschool; Cold Temperature; Cystic Fibrosis/drug therapy/microbiology/*physiopathology; Female; Forced Expiratory Volume/drug effects/physiology; Humans; Longitudinal Studies; Lung/*physiopathology; Male; Prospective Studies; Pseudomonas aeruginosa; Reproducibility of Results; Spirometry; Staphylococcus aureus; Statistics as Topic; Treatment Outcome  
  Abstract In a 4-year prospective study, we evaluated specific airway resistance (sRaw) by whole-body plethysmography, respiratory resistance by the interrupter technique, and respiratory resistance and reactance at 5 Hz by the impulse oscillation technique combined with measurement of responsiveness to bronchodilators and cold air in 30 children (mean [range] age 5.7 [2 to 8] years) with cystic fibrosis (CF). Spirometry was done at school age. Mean sRaw was consistently abnormal: the mean z score (SD) was 2.52 (2.02) (p < 0.001) at the start and was unchanged 36 months later at 2.74 (2.02). Mean z score (SD) for FEV(1) at first satisfactory measurement, at a mean age (range) of 6.1 (4.9-7.5) years was -1.2 (1.2) and was further reduced to -1.85 (1.2) 4 years from inclusion at a mean age (range) of 9.9 (6.8-12) years. Neither respiratory resistance by the interrupter technique nor the impulse oscillation technique demonstrated consistent abnormal levels. Patients with CF as a group did not differ from healthy subjects in responsiveness to bronchodilators and cold air. sRaw may be a useful tool in CF during early childhood. Reduced lung function was documented from consistently abnormal levels of sRaw and FEV1 during the study. Bronchodilator responsiveness and response to cold air challenge were normal.  
  Address Department of Pediatrics, Pulmonary Service, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. kgn@dadlnet.dk  
  Corporate Author Thesis  
  Impact Factor 12,996 First Author Nielsen, K.G. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Bisgaard, H.  
  ISSN 1073-449X ISBN Medium  
  Area Expedition Conference  
  Notes PMID:15028557 Approved no  
  Call Number Serial 174  
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