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Author Heitmann, B.L.; Anhoj, J.; Bisgaard, A.M.; Ward, L.; Bisgaard, H. url  doi
  Title Changes in body water distribution during treatment with inhaled steroid in pre-school children Type
  Year (down) 2004 Publication Annals of Human Biology Abbreviated Journal Ann Hum Biol  
  Volume 31 Issue 3 Pages 333-341  
  Keywords Administration, Inhalation; Androstadienes/*adverse effects/therapeutic use; Asthma/drug therapy; Body Water/*metabolism; Bronchodilator Agents/*adverse effects/therapeutic use; Budesonide/*adverse effects/therapeutic use; Child, Preschool; Cross-Over Studies; Double-Blind Method; Electric Impedance; Female; Fluticasone; Humans; Male; Skin/metabolism/ultrasonography  
  Abstract PRIMARY OBJECTIVE: The study aimed to examine the changes in water distribution in the soft tissue during systemic steroid activity. RESEARCH DESIGN: A three-way cross-over, randomized, placebo-controlled, double-blind trial was used, including 4 weeks of fluticasone propionate pMDI 200 microg b.i.d. delivered via Babyhaler, budesonide pressurized metered dose inhaler (pMDI) 200 microg b.i.d. delivered via Nebuchamber and placebo. Spacers were primed before use. In total, 40 children aged 1-3 years, with mild intermittent asthma were included. Twenty-five of the children completed all three treatments. At the end of each treatment period body impedance and skin ultrasonography were measured. METHODS AND PROCEDURES: We measured changes in water content of the soft tissues by two methods. Skin ultrasonography was used to detect small changes in dermal water content, and bioelectrical impedance was used to assess body water content and distribution. MAIN OUTCOMES AND RESULTS: We found an increase in skin density of the shin from fluticasone as measured by ultrasonography (p = 0.01). There was a tendency for a consistent elevation of impedance parameters from active treatments compared to placebo although overall this effect was not statistically significant (0.1 < p < 0.2). However, sub-analyses indicated a significant effect on whole-body and leg impedance from budesonide treatment (p < 0.05). CONCLUSION: Decreased growth during inhaled steroid treatment seems to partly reflect generalized changes in body water.  
  Address Research Unit for Dietary Studies and the Danish Epidemiology Science Centre at the Institute of Preventative Medicine, Copenhagen University Hospital, Copenhagen Denmark.  
  Corporate Author Thesis  
  Impact Factor 01,273 First Author Heitmann, B.L. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Bisgaard, H.  
  ISSN 0301-4460 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:15204348 Approved no  
  Call Number Serial 172  
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