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Author den Dekker, H.T.; Sonnenschein-van der Voort, A.M.M.; de Jongste, J.C.; Anessi-Maesano, I.; Arshad, S.H.; Barros, H.; Beardsmore, C.S.; Bisgaard, H.; Phar, S.C.; Craig, L.; Devereux, G.; van der Ent, C.K.; Esplugues, A.; Fantini, M.P.; Flexeder, C.; Frey, U.; Forastiere, F.; Gehring, U.; Gori, D.; van der Gugten, A.C.; Henderson, A.J.; Heude, B.; Ibarluzea, J.; Inskip, H.M.; Keil, T.; Kogevinas, M.; Kreiner-Moller, E.; Kuehni, C.E.; Lau, S.; Melen, E.; Mommers, M.; Morales, E.; Penders, J.; Pike, K.C.; Porta, D.; Reiss, I.K.; Roberts, G.; Schmidt, A.; Schultz, E.S.; Schulz, H.; Sunyer, J.; Torrent, M.; Vassilaki, M.; Wijga, A.H.; Zabaleta, C.; Jaddoe, V.W.V.; Duijts, L. url  doi
  Title Early growth characteristics and the risk of reduced lung function and asthma: A meta-analysis of 25,000 children Type Journal Article
  Year (down) 2016 Publication The Journal of Allergy and Clinical Immunology Abbreviated Journal J Allergy Clin Immunol  
  Volume 137 Issue 4 Pages 1026-35  
  Keywords Preterm birth; asthma; children; infant growth; low birth weight; lung function; meta-analysis  
  Abstract BACKGROUND: Children born preterm or with a small size for gestational age are at increased risk for childhood asthma. OBJECTIVE: We sought to assess the hypothesis that these associations are explained by reduced airway patency. METHODS: We used individual participant data of 24,938 children from 24 birth cohorts to examine and meta-analyze the associations of gestational age, size for gestational age, and infant weight gain with childhood lung function and asthma (age range, 3.9-19.1 years). Second, we explored whether these lung function outcomes mediated the associations of early growth characteristics with childhood asthma. RESULTS: Children born with a younger gestational age had a lower FEV1, FEV1/forced vital capacity (FVC) ratio, and forced expiratory volume after exhaling 75% of vital capacity (FEF75), whereas those born with a smaller size for gestational age at birth had a lower FEV1 but higher FEV1/FVC ratio (P < .05). Greater infant weight gain was associated with higher FEV1 but lower FEV1/FVC ratio and FEF75 in childhood (P < .05). All associations were present across the full range and independent of other early-life growth characteristics. Preterm birth, low birth weight, and greater infant weight gain were associated with an increased risk of childhood asthma (pooled odds ratio, 1.34 [95% CI, 1.15-1.57], 1.32 [95% CI, 1.07-1.62], and 1.27 [95% CI, 1.21-1.34], respectively). Mediation analyses suggested that FEV1, FEV1/FVC ratio, and FEF75 might explain 7% (95% CI, 2% to 10%) to 45% (95% CI, 15% to 81%) of the associations between early growth characteristics and asthma. CONCLUSIONS: Younger gestational age, smaller size for gestational age, and greater infant weight gain were across the full ranges associated with childhood lung function. These associations explain the risk of childhood asthma to a substantial extent.  
  Address Department of Pediatrics, Division of Respiratory Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands; Department of Pediatrics, Division of Neonatology, Erasmus University Medical Center, Rotterdam, The Netherlands. Electronic address:  
  Corporate Author Thesis  
  Impact Factor 11,476 First Author den Dekker, H.T. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Duijts, L.  
  ISSN 0091-6749 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:26548843 Approved no  
  Call Number Serial 17  
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