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Author Bisgaard, H. url  doi
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  Title A randomized trial of montelukast in respiratory syncytial virus postbronchiolitis Type Journal Article
  Year (down) 2003 Publication American Journal of Respiratory and Critical Care Medicine Abbreviated Journal Am J Respir Crit Care Med  
  Volume 167 Issue 3 Pages 379-383  
  Keywords Acetates/*therapeutic use; Bronchiolitis, Viral/*drug therapy; Double-Blind Method; Female; Humans; Infant; Leukotriene Antagonists/*therapeutic use; Male; Quinolines/*therapeutic use; Respiratory Syncytial Virus Infections/*drug therapy  
  Abstract Infants often develop reactive airway disease after respiratory syncytial virus (RSV) bronchiolitis. Cysteinyl-leukotrienes (cys-LT) are released during RSV infection and may contribute to the inflammation. We hypothesized that a cys-LT receptor antagonist would ameliorate reactive airway disease subsequent to RSV bronchiolitis. One hundred and thirty infants who were 3 to 36 months old, hospitalized with acute RSV bronchiolitis, were randomized into a double-blind, parallel comparison of 5-mg montelukast chewable tablets or matching placebo given for 28 days starting within 7 days of symptom debut. Infants with a suspected history of asthma were excluded. One hundred sixteen infants provided diary card data for the treatment period. Median age was 9 months. Infants on montelukast were free of any symptoms on 22% of the days and nights compared with 4% of the days and nights in infants on placebo (p = 0.015). Daytime cough was significantly reduced on active treatment (p = 0.04). Exacerbations were significantly delayed from montelukast compared with placebo (p < 0.05). In conclusion, cys-LT antagonist treatment reduces lung symptoms subsequent to RSV bronchiolitis.  
  Address Copenhagen Studies on Asthma in Childhood (COPSAC), Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. Bisgaard@copsac.dk  
  Corporate Author Study Group on Montelukast and Respiratory Syncytial Virus Thesis  
  Impact Factor 12,996 First Author Bisgaard, H. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Bisgaard, H.  
  ISSN 1073-449X ISBN Medium  
  Area Expedition Conference  
  Notes PMID:12406832 Approved no  
  Call Number Serial 162  
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