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Author Sampson, A.P.; Pizzichini, E.; Bisgaard, H. url  openurl
  Title Effects of cysteinyl leukotrienes and leukotriene receptor antagonists on markers of inflammation Type Journal Article
  Year (down) 2003 Publication The Journal of Allergy and Clinical Immunology Abbreviated Journal J Allergy Clin Immunol  
  Volume 111 Issue 1 Suppl Pages S49-59; discussion S59-61  
  Keywords Anti-Asthmatic Agents/*pharmacology/therapeutic use; Anti-Inflammatory Agents/*pharmacology/therapeutic use; Asthma/*drug therapy/genetics/immunology; Biomarkers/analysis/blood/urine; Bronchoalveolar Lavage Fluid/chemistry; Glutathione Transferase/genetics; Humans; Inflammation/blood/urine; Leukotriene Antagonists/*pharmacology/therapeutic use; Nitric Oxide/analysis; SRS-A/*physiology; Sputum/chemistry  
  Abstract The understanding that asthma pathophysiology includes an inflammatory component has spurred the more aggressive use of anti-inflammatory therapies and created a need for effective tools to measure inflammation. Biomarkers of airway inflammation proposed are obtained by methods that are direct but highly invasive (bronchial biopsy, bronchoalveolar lavage), moderately direct, and less invasive (indirect sputum, exhaled air, breath condensate) or indirect and least invasive (blood, urine). Several studies described in this review have implicated the cysteinyl leukotrienes (CysLTs) as inflammatory mediators in a wide range of diseases, implying that their biological activities reach far beyond acute bronchoconstriction, the activity traditionally ascribed to them. The validity of examining sputum for “biomarkers” has improved the understanding of asthma pathophysiology, optimization of asthma treatment and management, and investigation of the relation between CysLTs and airway inflammation in asthma. Nitric oxide is also a surrogate marker of asthma and reflects airway inflammation. The anti-inflammatory effects of the leukotriene receptor antagonists and the markers of their activity continue to grow.  
  Address Respiratory Cell Division at Southampton General Hospital, Southampton, UK  
  Corporate Author Thesis  
  Impact Factor 11,476 First Author Sampson, A.P. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Bisgaard, H.  
  ISSN 0091-6749 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:12532086 Approved no  
  Call Number Serial 161  
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