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Author Lipworth, B.J.; Lee, D.K.C.; Anhoj, J.; Bisgaard, H. url  openurl
  Title Effect of plastic spacer handling on salbutamol lung deposition in asthmatic children Type Journal Article
  Year (down) 2002 Publication British Journal of Clinical Pharmacology Abbreviated Journal Br J Clin Pharmacol  
  Volume 54 Issue 5 Pages 544-547  
  Keywords Administration, Inhalation; Albuterol/administration & dosage/*pharmacokinetics; Asthma/*drug therapy; Bronchodilator Agents/administration & dosage/*pharmacokinetics; Child; Child, Preschool; Cross-Over Studies; Humans; Lung/*chemistry; Metered Dose Inhalers/*standards; Nebulizers and Vaporizers; Plastics; Single-Blind Method  
  Abstract AIMS: To study the effects of electrostatics in a plastic spacer on the lung deposition of salbutamol in asthmatic children. METHODS: Twenty-five children (5-12 years) with mild asthma were given salbutamol hydrofluoroalkane pressurized metered dose inhaler 400 micro g via a 750 ml plastic spacer on separate days. Blood samples were taken for plasma salbutamol at 5, 10, 15 and 20 min after inhalation to measure lung bioavailability as a surrogate for relative lung dose. With immediate inhalation following actuation, a new rinsed spacer (NewRinsed ) was compared with a used spacer after repeated daily use (Used ), a spacer rinsed after repeated use (UsedRinsed ) and a spacer primed with benzalkonium chloride to avoid electrostatics (Primed1). In addition, spacers were evaluated using a 15 s inhalation delay following actuation with primed (PrimedDelay) and rinsed (RinsedDelay) spacers. Data were log transformed and expressed as geometric mean fold difference for the average plasma salbutamol concentration (Cav) over 20 min. RESULTS: There were significant differences (P < 0.05) in Cav (as geometric mean fold difference and 95% CI) between Primed1 vs NewRinsed 1.92 fold (95% CI 1.15, 3.20) and between Used vs NewRinsed 1.75 fold (1.11, 2.76). There were no significant differences comparing Primed1, Used or UsedRinsed. There were also significant differences (P < 0.05) between Primed1 vs PrimedDelay 2.34 fold (1.31, 4.19), or vs RinsedDelay 3.59 fold (2.15, 5.99); and for Used vs PrimedDelay 2.14 fold (1.24, 3.69), or vs RinsedDelay 3.28 fold (2.13, 5.04). CONCLUSIONS: The relative lung dose of salbutamol from a plastic spacer may differ considerably depending on spacer handling suggesting that nonelectrostatic spacers may be the best way forward.  
  Address Asthma & Allergy Research Group, Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, UK. b.j.lipworth@dundee.ac.uk  
  Corporate Author Thesis  
  Impact Factor 03,878 First Author Lipworth, B.J. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Bisgaard, H.  
  ISSN 0306-5251 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:12445036; PMCID:PMC1874464 Approved no  
  Call Number Serial 160  
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