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Author Thysen, A.H.; Rasmussen, M.A.; Kreiner-Moller, E.; Larsen, J.M.; Folsgaard, N.V.; Bonnelykke, K.; Stokholm, J.; Bisgaard, H.; Brix, S. url  doi
openurl 
  Title Season of birth shapes neonatal immune function Type Journal Article
  Year (down) 2016 Publication The Journal of Allergy and Clinical Immunology Abbreviated Journal J Allergy Clin Immunol  
  Volume 137 Issue 4 Pages 1238-1246  
  Keywords Birth season; airway mucosa; cord blood immune cells; neonatal immunity  
  Abstract BACKGROUND: Birth season has been reported to be a risk factor for several immune-mediated diseases. We hypothesized that this association is mediated by differential changes in neonatal immune phenotype and function with birth season. OBJECTIVE: We sought to investigate the influence of season of birth on cord blood immune cell subsets and inflammatory mediators in neonatal airways. METHODS: Cord blood was phenotyped for 26 different immune cell subsets, and at 1 month of age, 20 cytokines and chemokines were quantified in airway mucosal lining fluid. Multivariate partial least squares discriminant analyses were applied to determine whether certain immune profiles dominate by birth season, and correlations between individual cord blood immune cells and early airway immune mediators were defined. RESULTS: We found a birth season-related fluctuation in neonatal immune cell subsets and in early-life airway mucosal immune function. The seasonal airway immune pattern was associated with the number of activated and regulatory T cells in cord blood whereas it was independent of concomitant presence of pathogenic airway microbes. Specifically, summer newborns presented with the lowest levels of all cell types and mediators; fall newborns displayed high levels of activated T cells and mucosal IL-12p70, TNF-alpha, IL-13, IL-10, and IL-2; and winter newborns had the highest levels of innate immune cells, IL-5, type 17-related immune mediators, and activated T cells. CONCLUSION: Birth season fluctuations seem to affect neonatal immune development and result in differential potentiation of cord blood immune cells and early airway mucosal immune function.  
  Address Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark  
  Corporate Author Thesis  
  Impact Factor 11,476 First Author Thysen, A.H. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Brix, S.  
  ISSN 0091-6749 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:26581916 Approved no  
  Call Number Serial 16  
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