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Author Bonnelykke, K.; Pipper, C.B.; Bisgaard, H. url  doi
  Title Transfer of maternal IgE can be a common cause of increased IgE levels in cord blood Type Journal Article
  Year (down) 2010 Publication The Journal of Allergy and Clinical Immunology Abbreviated Journal J Allergy Clin Immunol  
  Volume 126 Issue 3 Pages 657-663  
  Keywords Female; Fetal Blood/*immunology; *Histocompatibility, Maternal-Fetal; Humans; Immunoglobulin E/*blood; Infant, Newborn; Pregnancy; Prenatal Exposure Delayed Effects  
  Abstract BACKGROUND: IgE in cord blood is thought to be a product of the fetus. A high level of total IgE is therefore used as a measure of atopic propensity in the newborn. We recently found strong evidence that allergen-specific IgE in cord blood was the result of transfer of maternal IgE to fetal blood or cord blood (maternofetal transfer) rather than fetal production. This also suggests that total IgE in cord blood might primarily be a maternal product. OBJECTIVE: We sought to determine to what extent increased levels of total IgE in cord blood is the result of maternofetal transfer of IgE. METHODS: Total IgE in cord blood was analyzed in a prospective birth cohort study. Maternofetal transfer of IgE was detected by means of high-sensitivity analyses of cord blood IgA and allergen-specific IgE and comparison with parental IgE levels and levels at 6 months of age. RESULTS: Forty-six percent of cord blood samples with increased IgE levels (>or=0.5 IU/mL) showed indication of maternofetal transfer of IgE. Maternal origin of IgE in these samples was validated by showing reduced levels of IgE at 6 months of age compared with samples with no indication of maternofetal transfer (geometric mean, 9.4 vs 5.4 IU/mL; P = .01). Maternofetal transfer was not appropriately accounted for by the conventional method of cord blood IgA measurement. CONCLUSIONS: Maternofetal transfer might be a common cause of increased cord blood IgE levels. Future studies should take potential maternofetal transfer into account or use other markers of atopy.  
  Address Copenhagen Prospective Studies on Asthma in Childhood, Danish Pediatric Asthma Center, Health Sciences, University of Copenhagen, Copenhagen University Hospital, Gentofte, Copenhagen, Denmark  
  Corporate Author Thesis  
  Impact Factor 11,476 First Author Bonnelykke, K. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Bisgaard, H.  
  ISSN 0091-6749 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:20816197 Approved no  
  Call Number Serial 153  
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