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Author Poorisrisak, P.; Halkjaer, L.B.; Thomsen, S.F.; Stensballe, L.G.; Kyvik, K.O.; Skytthe, A.; Schioetz, P.O.; Bisgaard, H. url  doi
  Title Causal direction between respiratory syncytial virus bronchiolitis and asthma studied in monozygotic twins Type Journal Article
  Year (down) 2010 Publication Chest Abbreviated Journal Chest  
  Volume 138 Issue 2 Pages 338-344  
  Keywords Asthma/diagnosis/*etiology; Bronchiolitis, Viral/*complications; Child; Child, Preschool; Diseases in Twins; Female; Humans; Hypersensitivity/diagnosis/etiology; Male; Registries; Respiratory Function Tests; Respiratory Syncytial Virus Infections/*complications; *Respiratory Syncytial Virus, Human; Twins, Monozygotic  
  Abstract BACKGROUND: Respiratory syncytial virus (RSV) bronchiolitis has been associated with later development of asthma, wheezing, abnormal pulmonary function, and sensitization. Our aim was to determine the differential effect within monozygotic (MZ) twin pairs discordant for severe RSV bronchiolitis in infancy on the subsequent development of asthma, pulmonary function, and allergy. METHODS: Thirty-seven MZ twin pairs discordant for RSV hospitalization in infancy (mean age 10.6 months) were compared at the mean age of 7.6 years for lung function, bronchial responsiveness, fractional exhaled nitric oxide (Feno), asthma diagnosis, use of asthma medication, and skin prick test to common inhalant allergens. RESULTS: There were no differences within MZ twin pairs discordant for RSV hospitalization in infancy with respect to pulmonary function, Feno, asthma prevalence, asthma medication use, or sensitization (P > .1 for all comparisons). CONCLUSIONS: We found no differential effect from severity of RSV infection on the development of asthma and allergy in MZ twin pairs discordant for RSV hospitalization in infancy. This argues against a specific effect of severe RSV infection in the development of asthma and allergy. Because of the small sample size, this study must be considered as a hypothesis-generating study.  
  Address Danish Pediatric Asthma Center, Copenhagen University Hospital, Gentofte, L213 Ledreborg alle 34, DK-2820 Copenhagen, Denmark  
  Corporate Author Thesis  
  Impact Factor 07,483 First Author Poorisrisak, P. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Bisgaard, H.  
  ISSN 0012-3692 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:20435661 Approved no  
  Call Number Serial 152  
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